ArticleProceedings of the National Academy of Sciences of the United States of America2000
An artificial transcriptional activating region with unusual properties.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- PthA4Molecular plant pathology · 2019Article
- High-throughput discovery of functional disordered regions: investigation of transactivation domains.Molecular systems biology · 2018Article
- The 9aaTAD Is Exclusive Activation Domain in Gal4.PloS one · 2017Article
- The 9aaTAD Transactivation Domains: From Gal4 to p53.PloS one · 2016Article
- Nucleosome distortion as a possible mechanism of transcription activation domain function.Epigenetics & chromatin · 2016Review
- Unfolding of the C-terminal domain of the J-protein Zuo1 releases autoinhibition and activates Pdr1-dependent transcription.Journal of molecular biology · 2013Article
- Coupling phosphate homeostasis to cell cycle-specific transcription: mitotic activation of Saccharomyces cerevisiae PHO5 by Mcm1 and Forkhead proteins.Molecular and cellular biology · 2009Article
- Tra1 as a screening target for transcriptional activation domain discovery.Bioorganic & medicinal chemistry letters · 2009Article
- Tetracycline analogue-regulated transgene expression in Plasmodium falciparum blood stages using Toxoplasma gondii transactivators.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- H2A.Z has a function reminiscent of an activator required for preferential binding to intergenic DNA.The EMBO journal · 2003Article
- The C-terminal region of cellular Qin oligomerizes: correlation with oncogenic transformation and transcriptional repression.Oncogene · 2003Article
- RNA sequences that work as transcriptional activating regions.Nucleic acids research · 2003Article
- Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs.Molecular and cellular biology · 2003Article
- A target essential for the activity of a nonacidic yeast transcriptional activator.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Interaction of a transcriptional repressor with the RNA polymerase II holoenzyme plays a crucial role in repression.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Transcriptional transactivation by selected short random peptides attached to lexA-GFP fusion proteins.BMC molecular biology · 2001Article
- Small-molecule regulators that mimic transcription factors.Biochimica et biophysica actaReview
- Riboactivators: transcription activation by noncoding RNA.Critical reviews in biochemistry and molecular biologyReview
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe a series of transcriptional activators generated by adding amino acids (eight in one case, six in another) to fragments of the yeast Saccharomyces cerevisiae activator Gal4 that dimerize and bind DNA. One of the novel activating regions identified by this procedure is unusual, compared with previously characterized yeast activating regions, in the following ways: it works more strongly than does Gal4's natural activating region as assayed in yeast; it is devoid of acidic residues; and several lines of evidence suggest that it sees targets in the yeast transcriptional machinery at least partially distinct from those seen by Gal4's activating region.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.