ArticleProceedings of the National Academy of Sciences of the United States of America2000
TOGA: an automated parsing technology for analyzing expression of nearly all genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 130 citations in OpenAlex.
- Suppression Subtractive Hybridization Versus Next-Generation Sequencing in Plant Genetic Engineering: Challenges and Perspectives.Molecular biotechnology · 2015Review
- From QTL to candidate gene: a genetic approach to alcoholism research.Current drug abuse reviews · 2009Review
- FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles.The Journal of biological chemistry · 2008Article
- iGentifier: indexing and large-scale profiling of unknown transcriptomes.Nucleic acids research · 2007Article
- Regulation of alpha-synuclein expression in alcohol-preferring and -non preferring rats.Journal of neurochemistry · 2006Article
- New prospects and strategies for drug target discovery in neurodegenerative disorders.NeuroRx : the journal of the American Society for Experimental NeuroTherapeutics · 2005Review
- Evaluation of the similarity of gene expression data estimated with SAGE and Affymetrix GeneChips.BMC genomics · 2005Article
- Regulation of alpha-synuclein expression in limbic and motor brain regions of morphine-treated mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Expression profiling and QTL analysis: a powerful complementary strategy in drug abuse research.Addiction biology · 2005Review
- Glutathione S-transferase 8-8 expression is lower in alcohol-preferring than in alcohol-nonpreferring rats.Alcoholism, clinical and experimental research · 2004Article
- Whole-genome expression profiling through fragment display and combinatorial gene identification.Nucleic acids research · 2004Article
- Gene expression in the pathophysiology of type 2 diabetes mellitus.Current diabetes reports · 2004Review
- Expression profiling using a hexamer-based universal microarray.Nature biotechnology · 2004Article
- Antipsychotic drug treatment alters expression of mRNAs encoding lipid metabolism-related proteins.Molecular psychiatry · 2003Article
- Y box-binding protein 1 induces resistance to oncogenic transformation by the phosphatidylinositol 3-kinase pathway.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Gene expression profiling of plant responses to abiotic stress.Functional & integrative genomics · 2003Review
- Quantitative cDNA-AFLP analysis for genome-wide expression studies.Molecular genetics and genomics : MGG · 2003Article
- alpha-Synuclein maps to a quantitative trait locus for alcohol preference and is differentially expressed in alcohol-preferring and -nonpreferring rats.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes.Journal of virology · 2003Article
- Heterogeneous expression of the triggering receptor expressed on myeloid cells-2 on adult murine microglia.Journal of neurochemistry · 2002Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
We have developed an automated, high-throughput, systematic cDNA display method called TOGA, an acronym for total gene expression analysis. TOGA utilizes 8-nt sequences, comprised of a 4-nt restriction endonuclease cleavage site and adjacent 4-nt parsing sequences, and their distances from the 3' ends of mRNA molecules to give each mRNA species in an organism a single identity. The parsing sequences are used as parts of primer-binding sites in 256 PCR-based assays performed robotically on tissue extracts to determine simultaneously the presence and relative concentration of nearly every mRNA in the extracts, regardless of whether the mRNA has been discovered previously. Visualization of the electrophoretically separated fluorescent assay products from different extracts displayed via a Netscape browser-based graphical user interface allows the status of each mRNA to be compared among samples and its identity to be matched with sequences of known mRNAs compiled in databases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.