ArticleProceedings of the National Academy of Sciences of the United States of America2000
The bst locus on mouse chromosome 16 is associated with age-related subretinal neovascularization.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 33 citations in OpenAlex.
- Review
- Retinal neovascularization induced by mutantInternational journal of ophthalmology · 2021Article
- Rb1/Rbl1/Vhl loss induces mouse subretinal angiomatous proliferation and hemangioblastoma.JCI insight · 2019Article
- Phenotypic and functional characterization of Bst+/- mouse retina.Disease models & mechanisms · 2015Article
- A subretinal matrigel rat choroidal neovascularization (CNV) model and inhibition of CNV and associated inflammation and fibrosis by VEGF trap.Investigative ophthalmology & visual science · 2010Article
- Animal models of choroidal and retinal neovascularization.Progress in retinal and eye research · 2010Review
- Ribosomal protein L24 defect in belly spot and tail (Bst), a mouse Minute.Development (Cambridge, England) · 2004Article
- Genetic factors of age-related macular degeneration.Progress in retinal and eye research · 2004Review
- Gene structure and chromosomal localization of mouse Opa1 : its exclusion from the Bst locus.BMC genetics · 2003Article
- A review of primary hereditary optic neuropathies.Journal of inherited metabolic disease · 2003Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Ocular neovascularization is the leading cause of blindness in developed countries and often causes rapid loss of vision in age-related macular degeneration. Acute visual loss is most often due to hemorrhage from new vessels that have extended from the choroid into the subretinal space. Growth of abnormal vessels beneath the retina in this condition is known as subretinal neovascularization (SRN). Age-related animal models of macular degeneration and SRN have not been described. Current animal models of SRN depend on chemical or physical stimuli to initiate growth of subretinal vessels. The genes responsible for age-related human macular degeneration with SRN have not been firmly identified. We report an angiogenic phenotype in Bst/+ mice that is age-related, clinically evident, and resembles human SRN. This represents a spontaneous, genetically determined model of SRN. Bst/+ mice offer the possibility of exploring the molecular mechanisms of SRN without the need for exogenous agents.
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Registered trials
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