ArticleCanadian journal of veterinary research = Revue canadienne de recherche veterinaire2000
Effects of vitamins A and E on superoxide production and intracellular signaling of neutrophils in Holstein calves.
Article in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
7 citing papers in PubMed, 22 citations in OpenAlex.
- Effects of vitamin E supplementation on cellular α-tocopherol concentrations of neutrophils in Holstein calves.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2013Trial
- α-Tocopherol and β-carotene concentrations in feed, colostrum, cow and calf serum in Swedish dairy herds with high or low calf mortality.Acta veterinaria Scandinavica · 2018Article
- Positive evidence for vitamin A role in prevention of type 1 diabetes.World journal of diabetes · 2016Review
- Risk factors for calf mortality in large Swedish dairy herds.Preventive veterinary medicine · 2011Article
- The role of retinol in the etiology and outcome of suppurative otitis media.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2009Article
- Complement receptor type 3 (CR3)- and Fc receptor (FcR)-mediated matrix metalloproteinase 9 (MMP-9) secretion and their intracellular signalling of bovine neutrophils.Veterinary research communications · 2007Article
- Effects of vitamin a supplementation on immune responses and correlation with clinical outcomes.Clinical microbiology reviews · 2005Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of vitamin A and vitamin E treatment on superoxide (O2-) production of neutrophils and their intracellular signaling, including intracellular Ca2+, protein kinase C (PKC), and tyrosine kinase (TK), were examined in Holstein calves. After treatment with vitamin A, heat-aggregated IgG (H-agg.IgG)-induced O2- production in neutrophils ranged from 3.7+/-0.4 to 4.3+/-0.9 nmol (mean +/- SD), and it was significantly (P<0.05) higher than that in the control calves. Opsonized zymosan (OPZ)-induced O2- production was similar with that of control calves. Intracellular signaling of neutrophils in vitamin A-treated calves was enhanced compared with that of control calves when stimulated with H-agg. IgG, but not with OPZ. After treatment with vitamin E, H-agg.IgG- and OPZ-induced O2- production of neutrophils ranged from 4.2+/-0.8 nmol to 5.4+/-0.5 nmol and from 7.8+/-0.6 nmol to 8.1+/-0.4 nmol (mean +/- SD), respectively, and they were significantly (P<0.05) higher than those in control calves. Intracellular signaling was also enhanced compared with that of control calves. These results suggested that the effects of vitamin A and E treatment on O2- production were correlated to changes in intracellular signaling of neutrophils in Holstein calves.
Indexed as
Identifiers
10680660PMC1189584W32119528What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.