ArticleInfection and immunity2000
Polymorphonuclear neutrophils are necessary for the recruitment of CD8(+) T cells in the liver in a pregnant mouse model of Chlamydophila abortus (Chlamydia psittaci serotype 1) infection.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- The Immune Response in the Uteri and Placentae ofPathogens (Basel, Switzerland) · 2023Article
- Recent advances and public health implications for environmental exposure to Chlamydia abortus: from enzootic to zoonotic disease.Veterinary research · 2022Review
- The spatial distribution of immune cell subpopulations in hepatocellular carcinoma.Cancer science · 2022Article
- Differential infiltration of neutrophils in T1-T2 versus T3-T4 oral squamous cell carcinomas: a preliminary study.BMC research notes · 2015Article
- Neutrophil trails guide influenza-specific CD8⁺ T cells in the airways.Science (New York, N.Y.) · 2015Article
- Enhanced neutrophil longevity and recruitment contribute to the severity of oviduct pathology during Chlamydia muridarum infection.Infection and immunity · 2011Article
- Human conjunctival transcriptome analysis reveals the prominence of innate defense in Chlamydia trachomatis infection.Infection and immunity · 2010Article
- B cells are essential for moderating the inflammatory response and controlling bacterial multiplication in a mouse model of vaccination against Chlamydophila abortus infection.Infection and immunity · 2009Article
- Critical role of IL-17RA in immunopathology of influenza infection.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Potential role of decoy B7-H4 in the pathogenesis of rheumatoid arthritis: a mouse model informed by clinical data.PLoS medicine · 2009Article
- The role of neutrophils in the upper and lower respiratory tract during influenza virus infection of mice.Respiratory research · 2008Article
- Both influenza-induced neutrophil dysfunction and neutrophil-independent mechanisms contribute to increased susceptibility to a secondary Streptococcus pneumoniae infection.Infection and immunity · 2006Article
- Roles of macrophages and neutrophils in the early host response to Bacillus anthracis spores in a mouse model of infection.Infection and immunity · 2006Article
- Neutrophil responses to Mycobacterium tuberculosis infection in genetically susceptible and resistant mice.Infection and immunity · 2005Article
- Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genes.The American journal of pathology · 2003Article
- B-cell-deficient mice show an exacerbated inflammatory response in a model of Chlamydophila abortus infection.Infection and immunity · 2002Article
- Endogenous interleukin-12 is not required for resolution of Chlamydophila abortus (Chlamydia psittaci serotype 1) infection in mice.Infection and immunity · 2001Article
- Neutrophil depletion during Toxoplasma gondii infection leads to impaired immunity and lethal systemic pathology.Infection and immunity · 2001Article
- In vivo involvement of polymorphonuclear neutrophils in Leishmania infantum infection.BMC microbiology · 2001Article
- Role of CD8(+)T cells in the host response to Chlamydia.Microbes and infectionReview
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of polymorphonuclear neutrophils (PMNs) in the development of the specific immune response against Chlamydophila abortus (Chlamydia psittaci serotype 1) infection was studied in a pregnant mouse model involving treatment with RB6-8C5 monoclonal antibody. PMN depletion significantly affected the immune response in the liver, in which the T-lymphocyte and F4/80(+) cell populations decreased, particularly the CD8(+) T-cell population. A Th1-like response, characterized by high levels of gamma interferon without detectable levels of interleukin 4 (IL-4) in serum, was observed in both depleted and nondepleted mice, although an increased production of IL-10 was detected in the depleted group. Our results suggest that PMNs play a very important role in the recruitment of other leukocyte populations to the inflammatory foci but have little influence in the polarization of the immune specific response toward a Th1-like response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.