ArticleInfection and immunity2000
Malaria infection induces rapid elevation of the soluble Fas ligand level in serum and subsequent T lymphocytopenia: possible factors responsible for the differences in susceptibility of two species of Macaca monkeys to Plasmodium coatneyi infection.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 59 citations in OpenAlex.
- SARS-CoV-2-associated lymphopenia: possible mechanisms and the role of CD147.Cell communication and signaling : CCS · 2024Review
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- A primate model of severe malarial anaemia: a comparative pathogenesis study.Scientific reports · 2019Article
- Functional genomics of simian malaria parasites and host-parasite interactions.Briefings in functional genomics · 2019Review
- Immunogenicity of the Plasmodium vivax merozoite surface protein 1 paralog in the induction of naturally acquired antibody and memory B cell responses.Malaria journal · 2017Article
- Malaria in cynomolgus monkeys used in toxicity studies in Japan.Journal of toxicologic pathology · 2016Article
- Malaria Parasites: The Great Escape.Frontiers in immunology · 2016Review
- Lymphocyte Perturbations in Malawian Children with Severe and Uncomplicated Malaria.Clinical and vaccine immunology : CVI · 2015Article
- CD4+ T cells apoptosis in Plasmodium vivax infection is mediated by activation of both intrinsic and extrinsic pathways.Malaria journal · 2015Article
- Leukogram Profile and Clinical Status in vivax and falciparum Malaria Patients from Colombia.Journal of tropical medicine · 2015Article
- Whole-genome sequencing and analysis of the Malaysian cynomolgus macaque (Macaca fascicularis) genome.Genome biology · 2012Article
- Lineage-specific positive selection at the merozoite surface protein 1 (msp1) locus of Plasmodium vivax and related simian malaria parasites.BMC evolutionary biology · 2010Article
- Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children.Malaria journal · 2008Article
- Blood coagulation, inflammation, and malaria.Microcirculation (New York, N.Y. : 1994) · 2008Review
- Cerebrospinal fluid and serum biomarkers of cerebral malaria mortality in Ghanaian children.Malaria journal · 2007Article
- Self-reactivities to the non-erythroid alpha spectrin correlate with cerebral malaria in Gabonese children.PloS one · 2007Article
- Characterization of peripheral blood lymphocyte subsets in patients with acute Plasmodium falciparum and P. vivax malaria infections at Wonji Sugar Estate, Ethiopia.Clinical and vaccine immunology : CVI · 2006Article
- Fas has a role in cerebral malaria, but not in proliferation or exclusion of the murine parasite in mice.Immunogenetics · 2005Article
- Soluble Fas ligand released by colon adenocarcinoma cells induces host lymphocyte apoptosis: an active mode of immune evasion in colon cancer.British journal of cancer · 2001Article
- What is the cause of lymphopenia in malaria?Infection and immunity · 2000Article
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7 authors at 3 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The intraerythrocytic stage of the simian malaria parasite Plasmodium coatneyi (CDC strain) was intravenously inoculated into two species of macaques with different susceptibilities to infection with this parasite, including four Japanese macaques (Macaca fuscata) and three cynomolgus macaques (M. fascicularis). The Japanese macaques infected with P. coatneyi developed severe clinical manifestations similar to those of severe human malaria and eventually became moribund, while the infected cynomolgus macaques, natural hosts of the parasite, exhibited no severe manifestation of disease except anemia and finally recovered from the infection. In the infected Japanese macaques, peripheral CD4(+) and CD8(+) T-cell populations were markedly decreased and fragmentation of chromosomal DNA in peripheral blood mononuclear cells was detected during the terminal period of infection, suggesting that apoptotic cell death was responsible at least in part for the T lymphocytopenia. Furthermore, soluble Fas ligand levels in sera of the infected Japanese macaques increased gradually to a markedly high level of 28. 83 +/- 10.56 pg/ml (n = 4) when the animals became moribund. On the other hand, none of the infected cynomolgus monkeys exhibited either T lymphocytopenia or elevated soluble Fas ligand level. These findings suggest that differences in immune response between the two species of macaque tested accounted for the contrasting outcomes after infection with the same isolate of malarial parasite, and in particular that a profound T lymphocytopenia due to Fas-derived apoptosis played a role in the fatal course of malaria in the infected Japanese macaques.
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