ArticleInfection and immunity2000
Actinobacillus pleuropneumoniae iron transport: a set of exbBD genes is transcriptionally linked to the tbpB gene and required for utilization of transferrin-bound iron.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 33 citations in OpenAlex.
- Infantile Anemia and Iron Treatments Affect the Gut Microbiome of Young Rhesus Monkeys.Microorganisms · 2025Article
- Review of advanced research on swineFrontiers in immunology · 2025Review
- Article
- Monoclonal antibodies against Actinobacillus pleuropneumoniae TonB2 protein expressed in Escherichia coli.Hybridoma (2005) · 2012Article
- Comparative profiling of the transcriptional response to iron restriction in six serotypes of Actinobacillus pleuropneumoniae with different virulence potential.BMC genomics · 2010Article
- Branched-chain amino acids are required for the survival and virulence of Actinobacillus pleuropneumoniae in swine.Infection and immunity · 2009Article
- Transcriptional profiling of Actinobacillus pleuropneumoniae under iron-restricted conditions.BMC genomics · 2007Article
- Identification of the Actinobacillus pleuropneumoniae leucine-responsive regulatory protein and its involvement in the regulation of in vivo-induced genes.Infection and immunity · 2007Article
- Real-time quantitative reverse transcription-PCR analysis of expression stability of Actinobacillus pleuropneumoniae housekeeping genes during in vitro growth under iron-depleted conditions.Applied and environmental microbiology · 2005Article
- Deletion of the ferric uptake regulator Fur impairs the in vitro growth and virulence of Actinobacillus pleuropneumoniae.Infection and immunity · 2005Article
- Enzymes involved in anaerobic respiration appear to play a role in Actinobacillus pleuropneumoniae virulence.Infection and immunity · 2005Article
- Two TonB systems in Actinobacillus pleuropneumoniae: their roles in iron acquisition and virulence.Infection and immunity · 2004Article
- Identification of Actinobacillus pleuropneumoniae genes important for survival during infection in its natural host.Infection and immunity · 2003Article
- fhuA of Actinobacillus pleuropneumoniae encodes a ferrichrome receptor but is not regulated by iron.Infection and immunity · 2003Article
- Actinobacillus pleuropneumoniae iron transport and urease activity: effects on bacterial virulence and host immune response.Infection and immunity · 2001Article
- Virulence factors of Actinobacillus pleuropneumoniae involved in colonization, persistence and induction of lesions in its porcine host.Veterinary researchReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Upon iron restriction, Actinobacillus pleuropneumoniae has been shown to express the transferrin-binding proteins TbpB and TbpA, both of which have been implied to be important virulence factors. In order to identify additional iron-regulated proteins, we cloned and analyzed the region upstream of the transferrin-binding protein genes in an A. pleuropneumoniae serotype 7 strain. We located immediately upstream of the tbpB gene two open reading frames which were 43% homologous to the neisserial ExbBD protein genes. By raising specific antibodies, we showed that ExbB is expressed under iron-limiting growth conditions only, and RT-PCR analysis revealed that the exbBD genes and the tbpB gene are transcribed on a single polycistronic mRNA. By constructing an isogenic and nonpolar exbBD mutant, we showed that the exbBD genes are required by A. pleuropneumoniae for utilization of transferrin-bound iron. Using PCR and Western blotting, we showed that the genetic organization found in A. pleuropneumoniae serotype 7 is similar in all 12 A. pleuropneumoniae serotype reference strains.
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