ArticleInfection and immunity2000
Mechanisms of the proinflammatory response of endothelial cells to Candida albicans infection.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 79 citations in OpenAlex.
- MUC16-dependent Renal Vascular Adhesion of Candida Promotes Tissue Invasion and Predicts Clinical Outcome in Candidemia.Research square · 2026Article
- Tumor-related fungi and crosstalk with gut fungi in the tumor microenvironment.Cancer biology & medicine · 2024Review
- Transcriptome Analysis of Human Dermal Cells Infected with Candida auris Identified Unique Pathogenesis/Defensive Mechanisms Particularly Ferroptosis.Mycopathologia · 2024Article
- Diabetes is accompanied by secretion of pro-atherosclerotic exosomes from vascular smooth muscle cells.Cardiovascular diabetology · 2023Article
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- IntestinalFrontiers in microbiology · 2022Article
- In vitro infection models to study fungal-host interactions.FEMS microbiology reviews · 2021Review
- A new perspective in sepsis treatment: could RGD-dependent integrins be novel targets?Drug discovery today · 2020Review
- Redundant Trojan horse and endothelial-circulatory mechanisms for host-mediated spread of Candida albicans yeast.PLoS pathogens · 2020Article
- Review
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- IFNα-mediated remodeling of endothelial cells in the bone marrow niche.Haematologica · 2017Article
- Article
- An integrated genomic and transcriptomic survey of mucormycosis-causing fungi.Nature communications · 2016Article
- Innate immune cell response upon Candida albicans infection.Virulence · 2016Review
- New signaling pathways govern the host response to C. albicans infection in various niches.Genome research · 2015Article
- In vitro models of hematogenously disseminated candidiasis.Virulence · 2014Article
- Article
- Article
- Divergent responses of different endothelial cell types to infection with Candida albicans and Staphylococcus aureus.PloS one · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Endothelial cells can influence significantly the host inflammatory response against blood-borne microbial pathogens. Previously, we found that endothelial cells respond to in vitro infection with Candida albicans by secreting interleukin 8 (IL-8) and expressing E-selectin, intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1). We have now examined the mechanisms mediating this endothelial cell response. We determined that C. albicans stimulated endothelial cells to synthesize tumor necrosis factor alpha (TNF-alpha), which in turn induced these infected cells to secrete IL-8 and express E-selectin by an autocrine mechanism. Expression of VCAM-1 was mediated not only by TNF-alpha but also by IL-1alpha and IL-1beta, all of which were synthesized by endothelial cells in response to C. albicans. These three cytokines remained primarily cell associated rather than being secreted. Candidal induction of ICAM-1 expression was independent of TNF-alpha, IL-1alpha, and IL-1beta. These observations demonstrate that different proinflammatory endothelial cell responses to C. albicans are induced by distinct mechanisms. A clear understanding of these mechanisms is important for therapeutically modulating the endothelial cell response to C. albicans and perhaps other opportunistic pathogens that disseminate hematogenously.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.