ArticleInfection and immunity2000
Allele substitution of the streptokinase gene reduces the nephritogenic capacity of group A streptococcal strain NZ131.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 36 citations in OpenAlex.
- Mechanisms that potentially contribute to the development of post-streptococcal glomerulonephritis.Pathogens and disease · 2024Review
- Epidemiology, pathogenesis, treatment and outcomes of infection-associated glomerulonephritis.Nature reviews. Nephrology · 2020Review
- Post-streptococcal acute glomerulonephritis in children: clinical features and pathogenesis.Pediatric nephrology (Berlin, Germany) · 2011Review
- Population biology of the human restricted pathogen, Streptococcus pyogenes.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2009Review
- Regulation of streptokinase expression by CovR/S in Streptococcus pyogenes: CovR acts through a single high-affinity binding site.Microbiology (Reading, England) · 2009Article
- Genome sequence of a nephritogenic and highly transformable M49 strain of Streptococcus pyogenes.Journal of bacteriology · 2008Article
- Seroreactivity against streptococcal DRS (distantly related to SIC) protein is a predictor for end-stage renal failure.Clinical and vaccine immunology : CVI · 2008Article
- Structural diversity of streptokinase and activation of human plasminogen.Infection and immunity · 2005Article
- Extracellular enzymes with immunomodulating activities: variations on a theme in Streptococcus pyogenes.Infection and immunity · 2003Review
- Rgg influences the expression of multiple regulatory loci to coregulate virulence factor expression in Streptococcus pyogenes.Infection and immunity · 2002Article
- Identification of Rgg-regulated exoproteins of Streptococcus pyogenes.Infection and immunity · 2001Article
- Pathogenesis of group A streptococcal infections.Clinical microbiology reviews · 2000Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the role of allelic variants of streptokinase in the pathogenesis of acute poststreptococcal glomerulonephritis (APSGN), site-specific integration plasmids were constructed, which contained either the non-nephritis-associated streptokinase gene (skc5) from the group C streptococcal strain Streptococcus equisimilis H46A or the nephritis-associated streptokinase gene (ska1) from the group A streptococcal nephritogenic strain NZ131. The plasmids were introduced by electroporation and homologous recombination into the chromosome of an isogenic derivative of strain NZ131, in which the streptokinase gene had been deleted and which had thereby lost its nephritogenic capacity in a mouse model of APSGN. The introduction of a non-nephritis-associated allelic variant of streptokinase did not rescue the nephritogenic capacity of the strain. The mutant and the wild-type strains produced equivalent amounts of streptokinase. Complementation of the ska deletion derivative with the original ska allele reconstituted the nephritogenicity of wild-type NZ131. The findings support the hypothesis that the role of streptokinase in the pathogenesis of APSGN is related to the allelic variant of the protein.
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