ArticleProceedings of the National Academy of Sciences of the United States of America2000
Hox cluster genomics in the horn shark, Heterodontus francisci.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 106 citations in OpenAlex.
- HOX-Gene Cluster Organization and Genome Duplications in Fishes and Mammals: Transcript Variant Distribution along the Anterior-Posterior Axis.International journal of molecular sciences · 2022Review
- An atlas of anterior hox gene expression in the embryonic sea lamprey head: Hox-code evolution in vertebrates.Developmental biology · 2019Article
- Review
- Functional and Comparative Genomics of Hoxa2 Gene cis-Regulatory Elements: Evidence for Evolutionary Modification of Ancestral Core Element Activity.Journal of developmental biology · 2016Article
- SkateBase, an elasmobranch genome project and collection of molecular resources for chondrichthyan fishes.F1000Research · 2014Article
- Evolution of Hox gene clusters in deuterostomes.BMC developmental biology · 2013Review
- Hox gene clusters of early vertebrates: do they serve as reliable markers for genome evolution?Genomics, proteomics & bioinformatics · 2011Review
- A general scenario of Hox gene inventory variation among major sarcopterygian lineages.BMC evolutionary biology · 2011Article
- Evolution of conserved non-coding sequences within the vertebrate Hox clusters through the two-round whole genome duplications revealed by phylogenetic footprinting analysis.Journal of molecular evolution · 2010Article
- Genome enablement of the notothenioidei: genome size estimates from 11 species and BAC libraries from 2 representative taxa.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2010Article
- Conservation of gene linkage in dispersed vertebrate NK homeobox clusters.Development genes and evolution · 2009Article
- Elephant shark (Callorhinchus milii) provides insights into the evolution of Hox gene clusters in gnathostomes.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Comparative genomics of chondrichthyan Hoxa clusters.BMC evolutionary biology · 2009Article
- Hox cluster duplication in the basal teleost Hiodon alosoides (Osteoglossomorpha).Theory in biosciences = Theorie in den Biowissenschaften · 2009Article
- Atypical relaxation of structural constraints in Hox gene clusters of the green anole lizard.Genome research · 2009Article
- Unexpectedly large number of conserved noncoding regions within the ancestral chordate Hox cluster.Development genes and evolution · 2008Article
- An ultraconserved Hox-Pbx responsive element resides in the coding sequence of Hoxa2 and is active in rhombomere 4.Nucleic acids research · 2008Article
- Biphasic Hoxd gene expression in shark paired fins reveals an ancient origin of the distal limb domain.PloS one · 2007Article
- Survey sequencing and comparative analysis of the elephant shark (Callorhinchus milii) genome.PLoS biology · 2007Article
- Evolutionary constraint on Otx2 neuroectoderm enhancers-deep conservation from skate to mouse and unique divergence in teleost.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
Reconstructing the evolutionary history of Hox cluster origins will lead to insights into the developmental and evolutionary significance of Hox gene clusters in vertebrate phylogeny and to their role in the origins of various vertebrate body plans. We have isolated two Hox clusters from the horn shark, Heterodontus francisci. These have been sequenced and compared with one another and with other chordate Hox clusters. The results show that one of the horn shark clusters (HoxM) is orthologous to the mammalian HoxA cluster and shows a structural similarity to the amphioxus cluster, whereas the other shark cluster (HoxN) is orthologous to the mammalian HoxD cluster based on cluster organization and a comparison with noncoding and Hox gene-coding sequences. The persistence of an identifiable HoxA cluster over an 800-million-year divergence time demonstrates that the Hox gene clusters are highly integrated and structured genetic entities. The data presented herein identify many noncoding sequence motifs conserved over 800 million years that may function as genetic control motifs essential to the developmental process.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.