ArticleProceedings of the National Academy of Sciences of the United States of America2000
Myeloblastin is a granulocyte colony-stimulating factor-responsive gene conferring factor-independent growth to hematopoietic cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 48 citations in OpenAlex.
- Lysine-specific demethylase 1 regulates hematopoietic stem cell expansion and myeloid cell differentiation.Cell death & disease · 2025Article
- Proteomic Profiling Differentiates Lymphoma Patients with and without Concurrent Myeloproliferative Neoplasia.Cancers · 2021Article
- Proteinase 3 Limits the Number of Hematopoietic Stem and Progenitor Cells in Murine Bone Marrow.Stem cell reports · 2018Article
- Proteinase 3; a potential target in chronic obstructive pulmonary disease and other chronic inflammatory diseases.Respiratory research · 2018Review
- Rethinking the bile acid/gut microbiome axis in cancer.Oncotarget · 2017Review
- Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis.The Journal of clinical investigation · 2015Article
- Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer.Genome research · 2012Article
- A label-free quantitative proteomics strategy to identify E3 ubiquitin ligase substrates targeted to proteasome degradation.Molecular & cellular proteomics : MCP · 2009Article
- Increased monocyte transcription of the proteinase 3 gene in small vessel vasculitis.Clinical and experimental immunology · 2005Article
- The - 564 A/G polymorphism in the promoter region of the proteinase 3 gene associated with Wegener's granulomatosis does not increase the promoter activity.Clinical and experimental immunology · 2004Article
- Analysis of VEGF-responsive genes involved in the activation of endothelial cells.Molecular cancer · 2003Article
- Expression of myeloid-specific genes in childhood acute lymphoblastic leukemia - a cDNA array study.Leukemia · 2002Article
- Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hematopoiesis depends on a pool of quiescent hematopoietic stem/progenitor cells. When exposed to specific cytokines, a portion of these cells enters the cell cycle to generate an amplified progeny. Myeloblastin (MBN) initially was described as involved in proliferation of human leukemia cells. The granulocyte colony-stimulating factor (G-CSF), which stimulates the proliferation of granulocytic precursors, up-regulates MBN expression. Here we show that constitutive overexpression of MBN confers factor-independent growth to murine bone marrow-derived Ba/F3/G-CSFR cells. Our results point to MBN as a G-CSF responsive gene critical to factor-independent growth and indicate that expression of the G-CSF receptor is a prerequisite to this process. A 91-bp MBN promoter region containing PU.1, C/EBP, and c-Myb binding sites is responsive to G-CSF treatment. Although PU.1, C/EBP, and c-Myb transcription factors all were critical for expression of MBN, its up-regulation by G-CSF was associated mainly with PU.1. These findings suggest that MBN is an important target of PU.1 and a key protease for factor-independent growth of hematopoietic cells.
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