ArticleThe Biochemical journal2000
Stimulation of cleavage of membrane proteins by calmodulin inhibitors.
Article in The Biochemical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 60 citations in OpenAlex.
- Overexpression of Nogo-A changes nerve growth factor signaling dynamics in PC12 cells.Cellular signalling · 2025Article
- The Relevance of Amyloid β-Calmodulin Complexation in Neurons and Brain Degeneration in Alzheimer's Disease.International journal of molecular sciences · 2021Review
- Pleiotropic Roles of Calmodulin in the Regulation of KRas and Rac1 GTPases: Functional Diversity in Health and Disease.International journal of molecular sciences · 2020Review
- Calmodulin Binding Proteins and Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2015Article
- Article
- Calmodulin adopts an extended conformation when interacting with L-selectin in membranes.PloS one · 2013Article
- Interaction of calmodulin with L-selectin at the membrane interface: implication on the regulation of L-selectin shedding.Journal of molecular biology · 2011Article
- ZP2 and ZP3 cytoplasmic tails prevent premature interactions and ensure incorporation into the zona pellucida.Journal of cell science · 2011Article
- The shedding of CD62L (L-selectin) regulates the acquisition of lytic activity in human tumor reactive T lymphocytes.PloS one · 2011Article
- Transmembrane and trans-subunit regulation of ectodomain shedding of platelet glycoprotein Ibalpha.The Journal of biological chemistry · 2010Article
- Glycoprotein nonmetastatic melanoma protein b, a melanocytic cell marker, is a melanosome-specific and proteolytically released protein.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI.The Journal of biological chemistry · 2010Article
- The secreted form of a melanocyte membrane-bound glycoprotein (Pmel17/gp100) is released by ectodomain shedding.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2010Article
- Neurotrophins induce neuregulin release through protein kinase Cdelta activation.The Journal of biological chemistry · 2009Article
- The identification of a calmodulin-binding domain within the cytoplasmic tail of angiotensin-converting enzyme-2.Endocrinology · 2009Article
- High shed antigen levels within tumors: an additional barrier to immunoconjugate therapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2008Review
- The vacuolar transporter chaperone (VTC) complex is required for microautophagy.Molecular biology of the cell · 2007Article
- Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity.Molecular and cellular biology · 2006Article
- Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca(2+) influx and PKC activation.The Journal of cell biology · 2004Article
- Calmodulin regulates intracellular trafficking of epidermal growth factor receptor and the MAPK signaling pathway.Molecular biology of the cell · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ectodomain of several membrane-bound proteins can be shed by proteolytic cleavage. The activity of the proteases involved in shedding is highly regulated by several intracellular second messenger pathways, such as protein kinase C (PKC) and intracellular Ca(2+). Recently, the shedding of the adhesion molecule L-selectin has been shown to be regulated by the interaction of calmodulin (CaM) with the cytosolic tail of L-selectin. Prevention of CaM-L-selectin interaction by CaM inhibitors or mutation of a CaM binding site in L-selectin induced L-selectin ectodomain shedding. Whether this action of CaM inhibitors also affects other membrane-bound proteins is not known. In the present paper we show that CaM inhibitors also stimulate the cleavage of several other transmembrane proteins, such as the membrane-bound growth factor precursors pro-transforming growth factor-alpha and pro-neuregulin-alpha2c, the receptor tyrosine kinase, TrkA, and the beta-amyloid precursor protein. Cleavage induced by CaM inhibitors was a rapid event, and resulted from the activation of a mechanism that was independent of PKC or intracellular Ca(2+) increases, but was highly sensitive to hydroxamic acid-based metalloprotease inhibitors. Mutational analysis of the intracellular domain of the TrkA receptor indicated that CaM inhibitors may stimulate membrane-protein ectodomain cleavage by mechanisms independent of CaM-substrate interaction.
Indexed as
Identifiers
10677354PMC1220861W1968098564What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.