A locus for autosomal dominant "pure" hereditary spastic paraplegia maps to chromosome 19q13.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

15 citing papers in PubMed, 80 citations in OpenAlex.

1. Tubular ER dysfunction in neurodegenerative diseases.Neurobiology of disease · 2025
   Review
2. New phenotype of RTN2-related spectrum: Complicated form of spastic paraplegia-12.Annals of clinical and translational neurology · 2022
   Article
3. Complexity of Generating Mouse Models to Study the Upper Motor Neurons: Let Us Shift Focus from Mice to Neurons.International journal of molecular sciences · 2019
   Review
4. Delving into the complexity of hereditary spastic paraplegias: how unexpected phenotypes and inheritance modes are revolutionizing their nosology.Human genetics · 2015
   Review
5. Hereditary spastic paraplegia: clinico-pathologic features and emerging molecular mechanisms.Acta neuropathologica · 2013
   Review
6. Mutations in the ER-shaping protein reticulon 2 cause the axon-degenerative disorder hereditary spastic paraplegia type 12.The Journal of clinical investigation · 2012
   Article
7. A novel locus for autosomal dominant "uncomplicated" hereditary spastic paraplegia maps to chromosome 8p21.1-q13.3.Human genetics · 2007
   Article
8. Hereditary spastic paraplegia.Current neurology and neuroscience reports · 2006
   Review
9. Narrowing of the critical region in autosomal recessive spastic paraplegia linked to the SPG5 locus.Neurogenetics · 2004
   Article
10. Science in motion: common molecular pathological themes emerge in the hereditary spastic paraplegias.Journal of medical genetics · 2003
    Review
11. Infantile-onset ascending hereditary spastic paralysis is associated with mutations in the alsin gene.American journal of human genetics · 2002
    Article
12. The prevalence of "pure" autosomal dominant hereditary spastic paraparesis in the island of Ireland.Journal of neurology, neurosurgery, and psychiatry · 2002
    Article
13. The Silver syndrome variant of hereditary spastic paraplegia maps to chromosome 11q12-q14, with evidence for genetic heterogeneity within this subtype.American journal of human genetics · 2001
    Article
14. Identification and expression analysis of spastin gene mutations in hereditary spastic paraplegia.American journal of human genetics · 2001
    Article
15. A new locus for autosomal recessive spastic paraplegia associated with mental retardation and distal motor neuropathy, SPG14, maps to chromosome 3q27-q28.American journal of human genetics · 2000
    Article

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

Authors and funding

5 authors at 3 institutions in 2 countries.

Funding

Abstract

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