ArticleAmerican journal of human genetics2000
Absence of significant linkage between phonological coding dyslexia and chromosome 6p23-21.3, as determined by use of quantitative-trait methods: confirmation of qualitative analyses.
Article in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 58 citations in OpenAlex.
- Targeted analysis of dyslexia-associated regions on chromosomes 6, 12 and 15 in large multigenerational cohorts.PloS one · 2025Article
- Study of Genetic Association WithClinical practice and epidemiology in mental health : CP & EMH · 2017Article
- DCDC2 genetic variants and susceptibility to developmental dyslexia.Psychiatric genetics · 2012Article
- The genetics of reading disabilities: from phenotypes to candidate genes.Frontiers in psychology · 2012Article
- In search of the perfect phenotype: an analysis of linkage and association studies of reading and reading-related processes.Behavior genetics · 2011Review
- Genetics of developmental dyslexia.European child & adolescent psychiatry · 2010Review
- The impact of genetic research on our understanding of normal cognitive ageing: 1995 to 2009.Neuropsychology review · 2009Review
- The genetics of reading disability.Current psychiatry reports · 2009Review
- Refinement of the 6p21.3 quantitative trait locus influencing dyslexia: linkage and association analyses.Human genetics · 2004Article
- A candidate gene for developmental dyslexia encodes a nuclear tetratricopeptide repeat domain protein dynamically regulated in brain.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Linkage disequilibrium mapping provides further evidence of a gene for reading disability on chromosome 6p21.3-22.Molecular psychiatry · 2003Article
- Evidence for linkage and association with reading disability on 6p21.3-22.American journal of human genetics · 2002Article
- Segregation analysis of phenotypic components of learning disabilities. I. Nonword memory and digit span.American journal of human genetics · 2000Article
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4 authors at 1 institution in 1 country.
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Abstract
We recently reported the absence of significant linkage of phonological coding dyslexia (PCD) to chromosome 6p23-p21.3 in 79 families with at least two affected siblings, even though linkage of dyslexia to this region has been found in four other independent studies. Whereas, in our previous analyses, we used a qualitative (affected, unaffected, or uncertain) PCD phenotype, here we report a reanalysis of linkage to the chromosome 6p region, by use of four quantitative measures of reading disability: phonological awareness, phonological coding, spelling, and rapid-automatized-naming (RAN) speed. The phonological-coding and spelling measures were highly correlated with each other and with the qualitative PCD phenotype, whereas the phonological-awareness and RAN-speed measures were only moderately correlated with the other measures. Using two-point and multipoint quantitative-trait sib-pair linkage analyses and variance-components analyses, we were unable to detect significant evidence for a locus in the 6p23-p21.3 region influencing any of the quantitative reading measures, supporting our previous qualitative linkage results. The most likely explanation for our inability to detect linkage between dyslexia and this region is that families with subtypes of dyslexia linked to this region are underrepresented in our sample, because of either chance or varying ascertainment criteria.
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