ArticleAmerican journal of human genetics2000
Removing the sampling restrictions from family-based tests of association for a quantitative-trait locus.
Article in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Innovative approach to identify multigenomic and environmental interactions associated with birth defects in family-based hybrid designs.Genetic epidemiology · 2021Article
- Causal inference in genetic trio studies.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Candidate-gene association analysis for a continuous phenotype with a spike at zero using parent-offspring trios.Journal of applied statistics · 2020Article
- Genetic Variants of Microtubule Actin Cross-linking Factor 1 (MACF1) Confer Risk for Parkinson's Disease.Molecular neurobiology · 2017Article
- Article
- hVMAT2: A Target of Individualized Medication for Parkinson's Disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016Article
- Statistical equivalent of the classical TDT for quantitative traits and multivariate phenotypes.Journal of genetics · 2015Review
- A multi-SNP association test for complex diseases incorporating an optimal P-value threshold algorithm in nuclear families.BMC genomics · 2015Article
- Association mapping of stem rust race TTKSK resistance in US barley breeding germplasm.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2014Article
- Family-based association test using both common and rare variants and accounting for directions of effects for sequencing data.PloS one · 2014Article
- Pathway-PDT: a flexible pathway analysis tool for nuclear families.BMC bioinformatics · 2013Article
- Family-based association mapping in crop species.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2013Review
- Dosage transmission disequilibrium test (dTDT) for linkage and association detection.PloS one · 2013Article
- Vitamin D receptor gene as a candidate gene for Parkinson disease.Annals of human genetics · 2011Article
- Article
- A review of family-based tests for linkage disequilibrium between a quantitative trait and a genetic marker.PLoS genetics · 2008Review
- Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principles.Human heredity · 2008Review
- Application of association mapping to understanding the genetic diversity of plant germplasm resources.International journal of plant genomics · 2008Article
- Visualizing genotype x phenotype relationships in the GAW15 simulated data.BMC proceedings · 2007Article
- A new test for family-based association mapping with inbred lines from plant breeding programs.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2006Article
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
One strategy for localization of a quantitative-trait locus (QTL) is to test whether the distribution of a quantitative trait depends on the number of copies of a specific genetic-marker allele that an individual possesses. This approach tests for association between alleles at the marker and the QTL, and it assumes that association is a consequence of the marker being physically close to the QTL. However, problems can occur when data are not from a homogeneous population, since associations can arise irrespective of a genetic marker being in physical proximity to the QTL-that is, no information is gained regarding localization. Methods to address this problem have recently been proposed. These proposed methods use family data for indirect stratification of a population, thereby removing the effect of associations that are due to unknown population substructure. They are, however, restricted in terms of the number of children per family that can be used in the analysis. Here we introduce tests that can be used on family data with parent and child genotypes, with child genotypes only, or with a combination of these types of families, without size restrictions. Furthermore, equations that allow one to determine the sample size needed to achieve desired power are derived. By means of simulation, we demonstrate that the existing tests have an elevated false-positive rate when the size restrictions are not followed and that a good deal of information is lost as a result of adherence to the size restrictions. Finally, we introduce permutation procedures that are recommended for small samples but that can also be used for extensions of the tests to multiallelic markers and to the simultaneous use of more than one marker.
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