ArticleAmerican journal of human genetics2000
Evidence for heterogeneity in recombination in the human pseudoautosomal region: high resolution analysis by sperm typing and radiation-hybrid mapping.
Article in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 110 citations in OpenAlex.
- Estimating Gene Conversion Tract Length and Rate From PacBio HiFi Data.Molecular biology and evolution · 2025Article
- Where is the boundary of the human pseudoautosomal region?American journal of human genetics · 2024Article
- Genomic and demographic processes differentially influence genetic variation across the human X chromosome.PloS one · 2023Article
- Article
- Recent expansion of the non-recombining sex-linked region on Silene latifolia sex chromosomes.Journal of evolutionary biology · 2022Article
- Chromosome-Level Genome Assemblies Expand Capabilities of Genomics for Conservation Biology.Genes · 2021Article
- Evolutionary dynamics of the human pseudoautosomal regions.PLoS genetics · 2021Article
- From molecules to populations: appreciating and estimating recombination rate variation.Nature reviews. Genetics · 2020Review
- The Location of the Pseudoautosomal Boundary inGenes · 2020Article
- Identification of a novel 15.5 kb SHOX deletion associated with marked intrafamilial phenotypic variability and analysis of its molecular origin.Journal of genetics · 2016Article
- A Track Record on SHOX: From Basic Research to Complex Models and Therapy.Endocrine reviews · 2016Review
- Hybrid Sterility in Rice (Oryza sativa L.) Involves the Tetratricopeptide Repeat Domain Containing Protein.Genetics · 2016Article
- Determinants of genetic diversity.Nature reviews. Genetics · 2016Review
- Genetic Diversity on the Human X Chromosome Does Not Support a Strict Pseudoautosomal Boundary.Genetics · 2016Article
- The Pseudoautosomal Regions of the U/V Sex Chromosomes of the Brown Alga Ectocarpus Exhibit Unusual Features.Molecular biology and evolution · 2015Article
- Recombination in the human Pseudoautosomal region PAR1.PLoS genetics · 2014Article
- Variation in genome-wide levels of meiotic recombination is established at the onset of prophase in mammalian males.PLoS genetics · 2014Article
- Expansion of the pseudo-autosomal region and ongoing recombination suppression in the Silene latifolia sex chromosomes.Genetics · 2013Article
- Sex modifies genetic effects on residual variance in urinary calcium excretion in rat (Rattus norvegicus).Genetics · 2012Article
- Fine scale analysis of crossover and non-crossover and detection of recombination sequence motifs in the honeybee (Apis mellifera).PloS one · 2012Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Accurate genetic and physical maps for the human pseudoautosomal region were constructed by use of sperm typing and high-resolution radiation-hybrid mapping. PCR analysis of 1,912 sperm was done with a manual, single-sperm isolation method. Data on four donors show highly significant linkage heterogeneity among individuals. The most significant difference was observed in a marker interval located in the middle of the Xp/Yp pseudoautosomal region, where one donor showed a particularly high recombination fraction. Longitudinal models were fitted to the data to test whether linkage heterogeneity among donors was significant for multiple intervals across the region. The results indicated that increased recombination in particular individuals and regions is compensated for by reduced recombination in neighboring intervals. To investigate correspondence between physical and genetic distances within the region, we constructed a high-resolution radiation-hybrid map containing 29 markers. The recombination fraction per unit of physical distance varies between regions ranging from 13- to 70-fold greater than the genome-average rate.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.