ArticleBrain research. Developmental brain research2000
Directional specificity and patterning of sensory axons in trigeminal ganglion-whisker pad cocultures.
Article in Brain research. Developmental brain research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Molecular determinants of the face map development in the trigeminal brainstem.The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology · 2006Review
- Target specific differentiation of peripheral trigeminal axons in rat-chick chimeric explant cocultures.Brain research. Developmental brain research · 2001Article
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3 authors.
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Abstract
In the rodent trigeminal pathway, trigeminal axons invade the developing whisker pad from a caudal to rostral direction. We investigated directional specificity of embryonic day (E) 15 rat trigeminal axons within this peripheral target field using explant cocultures. E15 trigeminal axons readily grow into the same age whisker pad explants and form follicle-related patterns along a caudal to rostral direction. They also can grow into this target from its lateral aspects. In contrast, they are unable to invade the whisker pad from the rostral (nasal) pole. We did not find any correlation between the distribution of extracellular matrix molecules and trigeminal axon growth preferences. We also examined age-related changes in trigeminal axon responsiveness to directional cues. E19 trigeminal axons readily grew into E15 whisker pad explants from either the caudal or the rostral pole. These results suggest the presence of growth permissive and repulsive cues that guide sensory axons in the whisker pad. Furthermore, trigeminal axons lose their responsiveness to growth inhibitory cues at later stages of development.
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Registered trials
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