ArticleThe EMBO journal2000
Hepatitis C virus core protein-induced loss of LZIP function correlates with cellular transformation.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 123 citations in OpenAlex.
- Exploring the role of Luman/CREB3 in regulating decidualization of mice endometrial stromal cells by comparative transcriptomics.BMC genomics · 2020Article
- Insights from the crystal structure of the chicken CREB3 bZIP suggest that members of the CREB3 subfamily transcription factors may be activated in response to oxidative stress.Protein science : a publication of the Protein Society · 2019Article
- Interplay between hepatitis C virus and ARF4.Virologica Sinica · 2017Article
- Article
- Transcriptional regulation of secretory capacity by bZip transcription factors.Frontiers in biology · 2015Article
- Roles of regulated intramembrane proteolysis in virus infection and antiviral immunity.Biochimica et biophysica acta · 2013Review
- Expression pattern implicates a potential role for luman recruitment factor in the process of implantation in uteri and development of preimplantation embryos in mice.The Journal of reproduction and development · 2013Article
- Article
- Hepatitis C viral heterogeneity based on core gene and an attempt to design small interfering RNA against strains resistant to interferon in rawalpindi, pakistan.Hepatitis monthly · 2012Article
- DC-STAMP knock-down deregulates cytokine production and T-cell stimulatory capacity of LPS-matured dendritic cells.BMC immunology · 2011Article
- Coevolution of the hepatitis C virus polyprotein sites in patients on combined pegylated interferon and ribavirin therapy.Journal of virology · 2011Article
- CREB3 subfamily transcription factors are not created equal: Recent insights from global analyses and animal models.Cell & bioscience · 2011Article
- Identification of a functional, CRM-1-dependent nuclear export signal in hepatitis C virus core protein.PloS one · 2011Article
- Inhibition of core gene of HCV 3a genotype using synthetic and vector derived siRNAs.Virology journal · 2010Article
- Oncogenic potential of hepatitis C virus proteins.Viruses · 2010Article
- Viral hepatocarcinogenesis.Oncogene · 2010Review
- Hepatitis C virus causes uncoupling of mitotic checkpoint and chromosomal polyploidy through the Rb pathway.Journal of virology · 2009Article
- A novel isoform of human LZIP negatively regulates the transactivation of the glucocorticoid receptor.Molecular endocrinology (Baltimore, Md.) · 2009Article
- Access of viral proteins to mitochondria via mitochondria-associated membranes.Reviews in medical virology · 2009Review
- Specific targeting of hepatitis C virus core protein by an intracellular single-chain antibody of human origin.Hepatology (Baltimore, Md.) · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Hepatitis C virus (HCV) is the major etiological agent of blood-borne non-A non-B hepatitis and a leading cause of liver cirrhosis and hepatocellular carcinoma worldwide. HCV core protein is a multifunctional protein with regulatory functions in cellular transcription and virus-induced transformation and pathogenesis. Here we report on the identification of a bZIP nuclear transcription protein as an HCV core cofactor for transformation. This bZIP factor, designated LZIP, activates CRE-dependent transcription and regulates cell proliferation. Loss of LZIP function in NIH 3T3 cells triggers morphological transformation and anchorage-independent growth. We show that HCV core protein aberrantly sequesters LZIP in the cytoplasm, inactivates LZIP function and potentiates cellular transformation. Our findings suggest that LZIP might serve a novel cellular tumor suppressor function that is targeted by the HCV core.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.