ArticleThe EMBO journal2000
C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 142 citations in OpenAlex.
- Article
- Thyroid C-Cell Biology and Oncogenic Transformation.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2025Review
- Review
- Opposing Spatially Segregated Function of Endogenous GDNF-RET Signaling in Cocaine Addiction.Biomolecules · 2023Article
- Preclinical Models of Neuroendocrine Neoplasia.Cancers · 2022Review
- Developmental role of PHD2 in the pathogenesis of pseudohypoxic pheochromocytoma.Endocrine-related cancer · 2021Article
- Article
- Article
- Chronic 2-Fold Elevation of Endogenous GDNF Levels Is Safe and Enhances Motor and Dopaminergic Function in Aged Mice.Molecular therapy. Methods & clinical development · 2020Article
- A Novel Phenotype of Germline Pathogenic Variants inFrontiers in endocrinology · 2020Review
- Development of the urogenital system is regulated via the 3'UTR of GDNF.Scientific reports · 2019Article
- Drosophila Model in Cancer: An Introduction.Advances in experimental medicine and biology · 2019Review
- The sympathetic nervous system: malignancy, disease, and novel functions.Cell and tissue research · 2018Article
- Rodent models of pheochromocytoma, parallels in rodent and human tumorigenesis.Cell and tissue research · 2018Review
- Activated ALK signals through the ERK-ETV5-RET pathway to drive neuroblastoma oncogenesis.Oncogene · 2018Article
- Non-mammalian models of multiple endocrine neoplasia type 2.Endocrine-related cancer · 2018Review
- Constitutive Ret signaling leads to long-lasting expression of amphetamine-induced place conditioning via elevation of mesolimbic dopamine.Neuropharmacology · 2018Article
- Multiple endocrine neoplasia 2B: Differential increase in enteric nerve subgroups in muscle and mucosa.World journal of gastrointestinal pathophysiology · 2017Article
- The RET E616Q Variant is a Gain of Function Mutation Present in a Family with Features of Multiple Endocrine Neoplasia 2A.Endocrine pathology · 2017Article
- Different RET gene mutation-induced multiple endocrine neoplasia type 2A in 3 Chinese families.Medicine · 2017Article
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Dominantly inherited multiple endocrine neoplasia type 2B (MEN2B) is characterized by tumors of the thyroid C-cells and adrenal chromaffin cells, together with ganglioneuromas of the gastrointestinal tract and other developmental abnormalities. Most cases are caused by substitution of threonine for Met918 in the RET receptor tyrosine kinase, which is believed to convert the RET gene to an oncogene by altering the enzyme's substrate specificity. We report the production of a mouse model of MEN2B by introduction of the corresponding mutation into the ret gene. Mutant mice displayed C-cell hyperplasia and chromaffin cell hyperplasia progressing to pheochromocytoma. Homozygotes did not develop gastrointestinal ganglioneuromas, but displayed ganglioneuromas of the adrenal medulla, enlargement of the associated sympathetic ganglia and a male reproductive defect. Surprisingly, homozygotes did not display any developmental defects attributable to a loss-of-function mutation. Thus, while our results support the conclusion that the Met918Thr substitution is responsible for MEN2B, they suggest that the substrate specificity of the RET kinase does not interfere with its normal role in the development of the kidneys and enteric nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.