ArticleJournal of clinical pathology1999
Differential expression of high molecular weight caldesmon in colorectal pericryptal fibroblasts and tumour stroma.
Article in Journal of clinical pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 16 citations in OpenAlex.
- Article
- Targeting the Epidermal Growth Factor Receptor Can Counteract the Inhibition of Natural Killer Cell Function Exerted by Colorectal Tumor-Associated Fibroblasts.Frontiers in immunology · 2018Article
- Expression of podoplanin/D2-40 in pericryptal stromal cells in superficial colorectal epithelial neoplasia.Medical molecular morphology · 2013Article
- Stromal cells in the human gut show ultrastructural features of fibroblasts and smooth muscle cells but not myofibroblasts.Journal of cellular and molecular medicine · 2011Article
- Histochemical localization of caldesmon isoforms in colon adenocarcinoma and lymph node metastases.Virchows Archiv : an international journal of pathology · 2011Article
- The actin-binding protein caldesmon is in spleen and lymph nodes predominately expressed by smooth-muscle cells, reticular cells, and follicular dendritic cells.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2010Article
- Presence of cancer-associated fibroblasts inversely correlates with Schwannian stroma in neuroblastoma tumors.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2009Article
- High molecular weight caldesmon positive stromal cells in the capsule of hepatocellular carcinomas.Journal of clinical pathology · 2004Article
- High molecular weight caldesmon positive stromal cells in the capsule of thyroid follicular tumours and tumour-like lesions.Journal of clinical pathology · 2002Article
- Alpha smooth muscle actin positive stromal cells in gastric carcinoma.Journal of clinical pathology · 2002Article
- Differential expression of CD34 in normal colorectal tissue, peritumoral inflammatory tissue, and tumour stroma.Journal of clinical pathology · 2000Article
- The myofibroblast: phenotypic characterization as a prerequisite to understanding its functions in translational medicine.Journal of cellular and molecular medicineReview
- Preliminary study of some of the main intratumor stroma components in gastric carcinomas.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate an extent of smooth muscle differentiation of pericryptal fibroblasts.
methodsExpression of high molecular weight caldesmon (h-CD) and alpha smooth muscle actin was investigated in 123 invasive colorectal adenocarcinomas and their surrounding non-neoplastic tissues.
resultsThe monoclonal antibody to h-CD, which showed predominantly positive immunostaining in well differentiated smooth muscle cells, recognised pericryptal fibroblasts, smooth muscle cells, and pericytes, but was not reactive to myofibroblasts. Antibody to alpha smooth muscle actin recognised not only pericryptal fibroblasts, smooth muscle cells, and pericytes but also myofibroblasts.
conclusionsPericryptal fibroblasts show greater smooth muscle differentiation than myofibroblasts and there is a possibility that they are well differentiated smooth muscle cells; h-CD is an excellent marker to discriminate pericryptal fibroblasts from myofibroblasts.
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