ArticleMolecular psychiatry2000
DRD4 exon III VNTR polymorphism-susceptibility factor for heroin dependence? Results of a case-control and a family-based association approach.
Article in Molecular psychiatry, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed.
- Neuropharmacological and Neurogenetic Correlates of Opioid Use Disorder (OUD) As a Function of Ethnicity: Relevance to Precision Addiction Medicine.Current neuropharmacology · 2020Review
- Shared Behavioral and Neurocircuitry Disruptions in Drug Addiction, Obesity, and Binge Eating Disorder: Focus on Group I mGluRs in the Mesolimbic Dopamine Pathway.ACS chemical neuroscience · 2019Review
- Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence.PloS one · 2013Article
- Genetics of dopamine receptors and drug addiction.Human genetics · 2012Review
- Molecular targets of alcohol action: Translational research for pharmacotherapy development and screening.Progress in molecular biology and translational science · 2011Review
- The DRD4 exon 3 VNTR polymorphism and addiction-related phenotypes: a review.Pharmacology, biochemistry, and behavior · 2009Review
- Genetic factors influencing alcohol dependence.British journal of pharmacology · 2008Review
- Dopamine D4 receptor polymorphism modulates cue-elicited heroin craving in Chinese.Psychopharmacology · 2006Article
- Genes associated with addiction: alcoholism, opiate, and cocaine addiction.Neuromolecular medicine · 2004Review
- The dopamine D4 receptor and the hyperactivity phenotype: a developmental-epidemiological study.Molecular psychiatry · 2002Article
- Dopamine D4 receptor gene (DRD4) is associated with Novelty Seeking (NS) and substance abuse: the saga continues...Molecular psychiatry · 2001Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dopaminergic abnormalities are implicated in the pathogenesis of substance abuse.1 Recently, two reports have been published suggesting an association between opioid dependence and presence of long alleles of the dopamine D4 receptor (DRD4) gene exon III VNTR.2, 3 We have attempted to replicate this finding using a two-tiered strategy employing independent case-control and family-based association samples. Our study was possibly the largest candidate gene association study to date on opioid dependence in a sample of 815 subjects, 396 of whom were patients. We found long alleles of the DRD4 exon III VNTR in similar frequency among 285 heroin addicts and 197 controls. Furthermore, no preferential transmission of long alleles to affected offspring was observed in a sample of 111 patients and their parents. Our results, therefore, do not support the hypothesis that alleles of the DRD4 exon III VNTR are susceptibility factors for opioid dependence in man. Molecular Psychiatry(2000) 5, 101-104.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.