ReviewGene therapy2000
Regulated gene expression systems.
Review in Gene therapy, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed.
- Regulatable in vivo gene expression via adaptamers.Molecular cell · 2026Article
- Development of a tetracycline-inducible programmed ribosomal frameshifting platform for sensitive regulation of mammalian gene expression.Nucleic acids research · 2026Article
- Regulatable In Vivo Gene Expression via Adaptamers.bioRxiv : the preprint server for biology · 2025Article
- Control of mammalian gene expression by modulation of polyA signal cleavage at 5' UTR.Nature biotechnology · 2024Article
- A step closer to safe and efficient mammalian gene regulation.Nature biotechnology · 2024Article
- Tenuous Transcriptional Threshold of Human Sex Determination. I. SRY and Swyer Syndrome at the Edge of Ambiguity.Frontiers in endocrinology · 2022Article
- Pulsed Electric Fields Alter Expression of NF-κB Promoter-Controlled Gene.International journal of molecular sciences · 2021Article
- An Ecdysone Receptor-based Singular Gene Switch for Deliberate Expression of Transgene with Robustness, Reversibility, and Negligible Leakiness.Journal of visualized experiments : JoVE · 2018Article
- CAGE: Chromatin Analogous Gene Expression.ACS synthetic biology · 2017Article
- Single vector non-leaky gene expression system for Drosophila melanogaster.Scientific reports · 2017Article
- Antibody gene transfer with adeno-associated viral vectors as a method for HIV prevention.Immunological reviews · 2017Review
- Ecdysone Receptor-based Singular Gene Switches for Regulated Transgene Expression in Cells and Adult Rodent Tissues.Molecular therapy. Nucleic acids · 2016Article
- Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells.The Journal of clinical investigation · 2015Article
- Human fetal liver cells for regulated ex vivo erythropoietin gene therapy.Molecular therapy. Methods & clinical development · 2014Article
- Plate-based diversity subset screening: an efficient paradigm for high throughput screening of a large screening file.Molecular diversity · 2013Article
- Physical non-viral gene delivery methods for tissue engineering.Annals of biomedical engineering · 2013Review
- Vector and helper genome rearrangements occur during production of helper-dependent adenoviral vectors.Human gene therapy methods · 2013Article
- A novel hybrid promoter responsive to pathophysiological and pharmacological regulation.Journal of molecular medicine (Berlin, Germany) · 2012Article
- Gene regulation systems for gene therapy applications in the central nervous system.Neurology research international · 2012Article
- Spatial control of gene expression within a scaffold by localized inducer release.Biomaterials · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most gene therapy research to date has focused on solving the delivery problem--getting genes efficiently and stably into target cells and tissues. Those working on systems for regulating the expression of genes once delivered have often been accused of trying to run before they can walk. Yet regulation is likely to be essential if gene therapy is to realize its full potential as a mainstream clinical option for delivering proteins. Dramatic progress has been made in designing and testing systems in which expression is controlled by orally active drugs. The next few years should see the first clinical trials of drug-regulated gene therapies.
Indexed as
Identifiers
10673717What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.