ArticleThe Journal of physiology2000
Chronic passive cigarette smoke exposure augments bronchopulmonary C-fibre inputs to nucleus tractus solitarii neurones and reflex output in young guinea-pigs.
Article in The Journal of physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 61 citations in OpenAlex.
- Inhalation of corticosteroid and β-agonist for persistent cough following pulmonary resection.General thoracic and cardiovascular surgery · 2012Trial
- Usefulness of suplatast tosilate for chronic cough following lung cancer surgery.General thoracic and cardiovascular surgery · 2009Trial
- Acute lung injury in neonatal rats causes postsynaptic depression in nucleus tractus solitarii second-order neurons.Respiratory physiology & neurobiology · 2019Article
- TRPA1 mediates changes in heart rate variability and cardiac mechanical function in mice exposed to acrolein.Toxicology and applied pharmacology · 2017Article
- Impact of Air Pollution on Age and Gender Related Increase in Cough Reflex Sensitivity of Healthy Children in Slovakia.Frontiers in physiology · 2016Article
- Review
- Case report: supraventricular arrhythmia after exposure to concentrated ambient air pollution particles.Environmental health perspectives · 2012Article
- TRPA1 and sympathetic activation contribute to increased risk of triggered cardiac arrhythmias in hypertensive rats exposed to diesel exhaust.Environmental health perspectives · 2011Article
- Distinct tachykinin NK(1) receptor function in primate nucleus tractus solitarius neurons is dysregulated after second-hand tobacco smoke exposure.British journal of pharmacology · 2011Article
- Peripheral mechanisms II: the pharmacology of peripherally active antitussive drugs.Handbook of experimental pharmacology · 2009Review
- Sensory nerves and airway irritability.Handbook of experimental pharmacology · 2009Review
- Central and peripheral mechanisms of narcotic antitussives: codeine-sensitive and -resistant coughs.Cough (London, England) · 2007Article
- Acid regurgitation associated with persistent cough after pulmonary resection: an observational study.Cough (London, England) · 2006Article
- Melatonin modulates the light-induced sympathoexcitation and vagal suppression with participation of the suprachiasmatic nucleus in mice.The Journal of physiology · 2003Article
- Lung C-fiber CNS reflex: role in the respiratory consequences of extended environmental tobacco smoke exposure in young guinea pigs.Environmental health perspectives · 2001Review
- Effects of passive inhalation of cigarette smoke on structural and functional parameters in the respiratory system of guinea pigs.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e TisilogiaArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Children chronically exposed to environmental tobacco smoke (passive cigarette smoke) have more wheeze, cough, bronchoconstriction, airway hyper-reactivity and mucous secretion, which may result, in part, from stimulation of the vagal bronchopulmonary C-fibre reflex. 2. Environmental tobacco smoke increases the sensitivity of bronchopulmonary C-fibre endings, but the physiological relevance of this sensitization is unknown. If this exposure augments the reflex responses via a central mechanism, then the responses of higher-order neurones in the reflex pathway and some components of the reflex output should also be augmented. 3. Guinea-pigs were chronically exposed to sidestream tobacco smoke (surrogate for environmental tobacco smoke) or filtered air for 5 days week-1 from age 1 to 6 weeks (age equivalent of human childhood) and were then anaesthetized, paralysed, ventilated and prepared with pneumothoraces. Baseline and left atrial capsaicin (0.5 and 2.0 microg kg-1)- evoked changes in the impulse activity of vagal C-fibre-activated neurones in nucleus tractus solitarii (NTS), phrenic nerve activity, tracheal pressure, arterial blood pressure and heart rate were compared in the two groups. 4. Sidestream smoke exposure significantly augmented the peak (P = 0.02) and duration (P = 0.01) of the NTS neuronal responses and the prolongation of expiratory time (P = 0.003) at the higher capsaicin dose. 5. Thus, the sensitization of the bronchopulmonary C-fibre endings by chronic exposure to sidestream tobacco smoke is transmitted to the NTS and is associated with a prolonged reflexively evoked expiratory apnoea. The findings may help to explain some related respiratory symptoms in children and be a factor in sudden infant death syndrome.
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