ArticleGut2000
Effect of endothelin and endothelin receptor blockade on capillary permeability in experimental pancreatitis.
Article in Gut, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 75 citations in OpenAlex.
- Effects of different resuscitation fluid on severe acute pancreatitis.World journal of gastroenterology · 2013Trial
- What you don't see matters: dual-energy CT in emergency radiology.Japanese journal of radiology · 2026Review
- 3D vascular mapping reveals multi-organ injury following severe acute pancreatitis.Theranostics · 2026Article
- Traditional Chinese medicine formulas alleviated acute pancreatitis via improvement of microcirculation: A systematic review and meta-analysis.Chinese herbal medicines · 2025Article
- [Clinical Manifestations of Early-Onset Capillary Leak Syndrome in Patients With Multiple Organ Failure Due to Severe Acute Pancreatitis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Article
- Value of Dual-Energy CT Perfusion Analysis in Patients with Acute Pancreatitis: Correlation and Discriminative Diagnostic Accuracy with Varying Disease Severity.Diagnostics (Basel, Switzerland) · 2022Article
- Molecular Dambusters: What Is Behind Hyperpermeability in Bradykinin-Mediated Angioedema?Clinical reviews in allergy & immunology · 2021Review
- Comparison of pancreatic microcirculation profiles in spontaneously hypertensive rats and Wistar-kyoto rats by laser doppler and wavelet transform analysis.Physiological research · 2020Article
- Effects of Yue-Bi-Tang on water metabolism in severe acute pancreatitis rats with acute lung-kidney injury.World journal of gastroenterology · 2020Article
- Dual-energy CT in early acute pancreatitis: improved detection using iodine quantification.European radiology · 2019Article
- [Idiopathic systemic capillary leak syndrome (Clarkson disease) : A rare cause of recurrent life-threatening edema].Der Internist · 2018Review
- Effect of mesenchymal stem cells on small intestinal injury in a rat model of acute necrotizing pancreatitis.Stem cell research & therapy · 2017Article
- Article
- Immunomodulatory therapies for acute pancreatitis.World journal of gastroenterology · 2014Review
- Regulation of blood pressure and salt homeostasis by endothelin.Physiological reviews · 2011Review
- The protecting effects and mechanisms of Baicalin and Octreotide on heart injury in rats with SAP.Mediators of inflammation · 2007Article
- Endothelin-1 receptor antagonist (LU-135252) improves the microcirculation and course of TNBS colitis in rats.Digestive diseases and sciences · 2006Article
- Selective COX-2 inhibition reduces leukocyte sticking and improves the microcirculation in TNBS colitis.Digestive diseases and sciences · 2006Article
- Hemoconcentration is a poor predictor of severity in acute pancreatitis.World journal of gastroenterology · 2005Article
- Effect of endothelin-1 receptor antagonists on histological and ultrastructural changes in the pancreas and trypsinogen activation in the early course of caerulein-induced acute pancreatitis in rats.World journal of gastroenterology · 2005Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCapillary leakage with fluid loss into the third space contributes to many of the early systemic complications in severe acute pancreatitis. There has been increasing interest in endothelin as one of the factors affecting capillary permeability.
aimTo elucidate further the role of endothelin in the development of capillary leakage in acute pancreatitis by investigating the effect of exogenous endothelin administration and endothelin receptor blockade in sham operated animals and two models of acute pancreatitis.
methodsDetermination of capillary permeability in the pancreas and colonic mucosa by quantifying extravasation of fluorescein labelled dextran using a novel computer assisted video image analysis system.
resultsPancreatic and colonic capillary permeability increased stepwise from mild to severe acute pancreatitis. Endothelin increased pancreatic and colonic capillary permeability in healthy animals and animals with mild acute pancreatitis but had no additional adverse effect in severe acute pancreatitis. Endothelin receptor blockade decreased pancreatic capillary permeability in sham operated rats but had no effect on the colon. In mild and severe acute pancreatitis, endothelin receptor blockade stabilised increased capillary permeability in both the pancreas and colon.
conclusionsEndothelin plays an important role in mediating capillary permeability in the pancreas. In severe pancreatitis, it increases capillary permeability even outside the pancreas, thereby contributing to capillary leakage. Endothelin receptor blockade significantly reduces capillary permeability in acute pancreatitis both in and outside the pancreas, suggesting a therapeutic approach to counteract capillary leakage in severe acute pancreatitis.
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