ArticleCirculation2000
Extent and direction of arterial remodeling in stable versus unstable coronary syndromes : an intravascular ultrasound study.
Article in Circulation, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 182 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Rosuvastatin on the Density Score of Coronary Artery Calcification in CAD Patients With Diabetes Mellitus
Correlation Between Serum Markers of Unstable Plaque and Virtual Histology of Unstable Plaque Visualized by IVUS
Who cites it
182 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Multi-ancestry genome-wide study identifies effector genes and druggable pathways for coronary artery calcification.Nature genetics · 2023Pooled it
- TGFB1 genetic polymorphisms and coronary heart disease risk: a meta-analysis.BMC medical genetics · 2012Pooled it
- Layered plaque and plaque volume in patients with acute coronary syndromes.Journal of thrombosis and thrombolysis · 2023Trial
- Comparison of the effects of pitavastatin versus pravastatin on coronary artery plaque phenotype assessed by tissue characterization using serial virtual histology intravascular ultrasound.Heart and vessels · 2015Trial
- Impacts of age on coronary atherosclerosis and vascular response to statin therapy.Heart and vessels · 2014Trial
- Differences in intravascular ultrasound and histological findings in culprit coronary plaques between ST-segment elevation myocardial infarction and stable angina.Journal of thrombosis and thrombolysis · 2014Trial
- Coronary artery diameter related to calcium scores and coronary risk factors as measured with multidetector computed tomography: a substudy of the ACCURACY trial.Texas Heart Institute journal · 2013Trial
- Detection of coronary plaques using MR coronary vessel wall imaging: validation of findings with intravascular ultrasound.European radiology · 2013Trial
- Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): a randomised clinical trial.Lancet (London, England) · 2011Trial
- Trial
- Association of insulin resistance and positive coronary artery remodeling and plaque burden in patients with acute coronary syndrome.BMC cardiovascular disorders · 2026Article
- Coronary atherosclerosis: plaque volume determines long-term prognosis.European heart journal. Cardiovascular Imaging · 2026Article
- Evaluation of different artificial intelligence-based coronary artery calcium scoring algorithms in nongated chest computed tomography.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2026Article
- Association of cerebrovascular morphology with ischaemic stroke considering intracranial stenosis.Brain communications · 2026Article
- Factors Contributing to Low Utilization of Intracoronary Imaging in Clinical Practice: A White Paper.Journal of the Society for Cardiovascular Angiography & Interventions · 2025Review
- Intravascular Ultrasound Imaging-Guided Percutaneous Coronary Intervention: Evidence and Practical Implications.Methodist DeBakey cardiovascular journal · 2025Review
- Association between perforator stroke after middle cerebral artery elective stenting and arterial remodeling patterns: a high-resolution MRI-based retrospective cohort study.Quantitative imaging in medicine and surgery · 2024Article
- Whys and Wherefores of Coronary Arterial Positive Remodeling.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- Using artificial intelligence to study atherosclerosis from computed tomography imaging: A state-of-the-art review of the current literature.Atherosclerosis · 2024Review
- Calcification Formation for Development, Defense, and Repair of the Human Body?Journal of clinical medicine · 2024Article
122 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe morphological characteristics of coronary plaques in patients with stable versus unstable coronary syndromes have been described in vivo with intravascular ultrasound, but the relationship between arterial remodeling and clinical presentation is not well known. METHODS AND
resultsWe studied 85 patients with unstable and 46 patients with stable coronary syndromes using intravascular ultrasound before coronary intervention. The lesion site and a proximal reference site were analyzed. The remodeling ratio (RR) was defined as the ratio of the external elastic membrane (EEM) area at the lesion to that at the proximal reference site. Positive remodeling was defined as an RR >1.05 and negative remodeling as an RR <0.95. Plaque area (13.9+/-5.5 versus 11.1+/-4.8 mm(2); P=0.005), EEM area (16.1+/-6.2 versus 13.0+/-4.8 mm(2); P=0. 004), and the RR (1.06+/-0.2 versus 0.94+/-0.2; P=0.008) were significantly greater at target lesions in patients with unstable syndromes than in patients with stable syndromes. Positive remodeling was more frequent in unstable than in stable lesions (51. 8% versus 19.6%), whereas negative remodeling was more frequent in stable lesions (56.5% versus 31.8%) (P=0.001).
conclusionsPositive remodeling and larger plaque areas were associated with unstable clinical presentation, whereas negative remodeling was more common in patients with stable clinical presentation. This association between the extent of remodeling and clinical presentation may reflect a greater tendency of plaques with positive remodeling to cause unstable coronary syndromes.
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Identifiers
10673250What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.