ArticleNeuroscience2000
Activation of the parapyramidal region in the ventral medulla stimulates gastric acid secretion through vagal pathways in rats.
Article in Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- The Impact of Stress, Microbial Dysbiosis, and Inflammation on Necrotizing Enterocolitis.Microorganisms · 2023Review
- A Review of the Impact of Maternal Prenatal Stress on Offspring Microbiota and Metabolites.Metabolites · 2023Review
- Mechanisms and prevention of acid reflux induced laryngospasm in seizing rats.Epilepsy & behavior : E&B · 2020Article
- The role of the commensal microbiota in adaptive and maladaptive stressor-induced immunomodulation.Hormones and behavior · 2017Review
- Brainstem neuropeptides and vagal protection of the gastric mucosal against injury: role of prostaglandins, nitric oxide and calcitonin-gene related peptide in capsaicin afferents.Current medicinal chemistry · 2012Review
- Stress-related alterations of acyl and desacyl ghrelin circulating levels: mechanisms and functional implications.Peptides · 2011Review
- Cold ambient temperature reverses abdominal surgery-induced delayed gastric emptying and decreased plasma ghrelin levels in rats.Peptides · 2010Article
- Multiple thermoregulatory effectors with independent central controls.European journal of applied physiology · 2010Review
- Role of brainstem TRH/TRH-R1 receptors in the vagal gastric cholinergic response to various stimuli including sham-feeding.Autonomic neuroscience : basic & clinical · 2006Review
- Orexin inputs to caudal raphé neurons involved in thermal, cardiovascular, and gastrointestinal regulation.Histochemistry and cell biology · 2005Article
- Involvement of glutamate and gamma-amino-butyric acid receptor systems on gastric acid secretion induced by activation of kappa-opioid receptors in the central nervous system in rats.British journal of pharmacology · 2003Article
- Neural mechanism of acupuncture-induced gastric relaxations in rats.Digestive diseases and sciences · 2003Article
- Importance of medullary thyrotropin-releasing hormone in brain-gut circuits regulating gastric integrity: preclinical studies.Journal of gastroenterology · 2002Review
- Acute cold exposure induces vagally mediated Fos expression in gastric myenteric neurons in conscious rats.American journal of physiology. Gastrointestinal and liver physiology · 2001Article
- Localization of thyroid hormone receptor beta2 in the ventral medullary neurons that synthesize thyrotropin-releasing hormone.Brain research · 2000Article
- Impact of stressor exposure on the interplay between commensal microbiota and host inflammation.Gut microbesReview
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Neurons synthesizing thyrotropin-releasing hormone, substance P and serotonin in the medullary caudal raphe nuclei project to the dorsal vagal complex and play a role in the central vagal regulation of gastric function. Neurons in the parapyramidal region in the ventral medulla share similar biochemical coding and projections as those in the caudal raphe nuclei. The role of the parapyramidal region in the autonomic regulation of gastric acid secretion was investigated in urethane-anesthetized rats. Unilateral microinjection of kainate into the parapyramidal region at 10, 15 and 20 ng induced a dose-related stimulation of gastric acid secretion (net increases: 22.2+/-11.2, 40.5+/-8.5 and 89.8+/-19.4 micromol/60 min, respectively), while injection of vehicle had no effect (net change: -0.1+/-1.4 micromol/60 min). Time-course studies showed a nine-fold peak increase over basal at 30 min after parapyramidal injection of kainate (20 ng) and acid secretion returned to basal level at 70 min. Microinjections of kainate (15-20 ng) outside the parapyramidal region or into the parapyramidal region in vagotomized rats had no effect. Exposure to cold (4 degrees C) for 2 h, which is known to induce vagally mediated gastric secretory and motor responses through medullary thyrotropin-releasing hormone pathways, increased the number of Fos-positive cells in the caudal, middle and rostral parts of the parapyramidal region to 4.3+/-0.4, 9.4+/-0.9 and 18.4+/-1.6/section, respectively, compared with 0.1+/-0. 1, 0.1+/-0.0 and 0.7+/-0.6/section, respectively, in rats maintained at room temperature. Most of the Fos-labeled cells co-expressed pro-thyrotropin-releasing hormone messenger RNA signal and/or were serotonin immunoreactive. These data show that chemical activation of neurons in the parapyramidal region results in a vagal-dependent stimulation of gastric acid secretion and that acute cold exposure activates parapyramidal neurons containing pro-thyrotropin-releasing hormone and/or serotonin, suggesting a potential role of the parapyramidal region, in addition to the caudal raphe nuclei, as medullary sites involved in the vagal regulation of gastric function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.