ArticleMolecular and cellular biology2000
Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Glia generate distinct visual processing centres by locally inhibiting ERK activity in an optic lobe neuroepithelium.bioRxiv : the preprint server for biology · 2026Article
- Engrailed, Suppressor of fused and Roadkill modulate the Drosophila GLI transcription factor Cubitus interruptus at multiple levels.Development (Cambridge, England) · 2022Article
- Dpp and Hedgehog promote the glial response to neuronal apoptosis in the developing Drosophila visual system.PLoS biology · 2021Article
- Hedgehog signaling establishes precursors for germline stem cell niches by regulating cell adhesion.The Journal of cell biology · 2017Article
- Autocrine Activation of the Wnt/β-Catenin Pathway by CUX1 and GLIS1 in Breast Cancers.Biology open · 2014Article
- Inhibition of Hedgehog signaling in the gastrointestinal tract: targeting the cancer microenvironment.Cancer treatment reviews · 2014Review
- Message in a nucleus: signaling to the transcriptional machinery.Current opinion in genetics & development · 2008Review
- GLI2-specific transcriptional activation of the bone morphogenetic protein/activin antagonist follistatin in human epidermal cells.The Journal of biological chemistry · 2008Article
- Regulation of Hedgehog signaling: a complex story.Biochemical pharmacology · 2004Review
- The acetyltransferase activity of CBP is required for wingless activation and H4 acetylation in Drosophila melanogaster.Molecular and cellular biology · 2002Article
- The interaction between the coactivator dCBP and Modulo, a chromatin-associated factor, affects segmentation and melanotic tumor formation in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Functional interaction between the coactivator Drosophila CREB-binding protein and ASH1, a member of the trithorax group of chromatin modifiers.Molecular and cellular biology · 2000Article
- Recruitment of CREB binding protein is sufficient for CREB-mediated gene activation.Molecular and cellular biology · 2000Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
CREB-binding protein (CBP) serves as a transcriptional coactivator in multiple signal transduction pathways. The Drosophila homologue of CBP, dCBP, interacts with the transcription factors Cubitus interruptus (CI), MAD, and Dorsal (DL) and functions as a coactivator in several signaling pathways during Drosophila development, including the hedgehog (hh), decapentaplegic (dpp), and Toll pathways. Although dCBP is required for the expression of the hh target genes, wingless (wg) and patched (ptc) in vivo, and potentiates ci-mediated transcriptional activation in vitro, it is not known that ci absolutely requires dCBP for its activity. We used a yeast genetic screen to identify several ci point mutations that disrupt CI-dCBP interactions. These mutant proteins are unable to transactivate a reporter gene regulated by ci binding sites and have a lower dCBP-stimulated activity than wild-type CI. When expressed exogenously in embryos, the CI point mutants cannot activate endogenous wg expression. Furthermore, a CI mutant protein that lacks the entire dCBP interaction domain functions as a negative competitor for wild-type CI activity, and the expression of dCBP antisense RNAs can suppress CI transactivation in Kc cells. Taken together, our data suggest that dCBP function is necessary for ci-mediated transactivation of wg during Drosophila embryogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.