ReviewAntiviral research1999
Respiratory viral infections in the elderly.
Review in Antiviral research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 84 citations in OpenAlex.
- Trial
- Priming mucosal pathogen-agnostic innate immunity with an intranasal TLR2/6 agonist in an aged population.ERJ open research · 2025Article
- Co-Infection Rates between SARS-CoV-2 and RSV in Oropharyngeal, Nasopharyngeal Aspirate and Saliva Samples of COVID-19 Patients, Shiraz, South of Iran.Journal of dentistry (Shiraz, Iran) · 2023Article
- Reduction in respiratory viral infections among hospitalized older adults during the COVID-19 pandemic.Journal of the American Geriatrics Society · 2021Article
- Intranasal Vaccine Delivery Technology for Respiratory Tract Disease Application with a Special Emphasis on Pneumococcal Disease.Vaccines · 2021Review
- Lower respiratory tract infection in the community: associations between viral aetiology and illness course.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2021Article
- Community-Acquired Respiratory Viruses in Transplant Patients: Diversity, Impact, Unmet Clinical Needs.Clinical microbiology reviews · 2019Review
- Respiratory tract virus infections in the elderly with pneumonia.BMC geriatrics · 2019Article
- Virus Etiology of Airway Illness in Elderly Adults.Journal of the American Geriatrics Society · 2016Article
- Influenza and Respiratory Syncytial viral infections in Malaysia: Demographic and Clinical perspective.Pakistan journal of medical sciences · 2014Article
- Rates of hospitalizations for respiratory syncytial virus, human metapneumovirus, and influenza virus in older adults.The Journal of infectious diseases · 2012Article
- T-cell biology in aging, with a focus on lung disease.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Review
- Age-associated impaired plasmacytoid dendritic cell functions lead to decreased CD4 and CD8 T cell immunity.Age (Dordrecht, Netherlands) · 2011Article
- Defective interfering virus protects elderly mice from influenza.Virology journal · 2011Article
- Detection of respiratory viruses by molecular methods.Clinical microbiology reviews · 2008Review
- Human coronavirus infection among children with acute lower respiratory tract infection in Thailand.Intervirology · 2007Article
- Roles of human parainfluenza virus type 3 bases 13 to 78 in replication and transcription: identification of an additional replication promoter element and evidence for internal transcription initiation.Journal of virology · 2006Article
- Chronic cough due to acute bronchitis: ACCP evidence-based clinical practice guidelines.Chest · 2006Review
- Changes in mortalities and hospital admissions associated with holidays and respiratory illness: implications for medical services.Journal of evaluation in clinical practice · 2005Article
- Management of acute bronchitis in healthy adults.Infectious disease clinics of North America · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viral respiratory infections represent a significant challenge for those interested in improving the health of the elderly. Influenza continues to result in a large burden of excess morbidity and mortality. Two effective measures, inactivated influenza vaccine, and the antiviral drugs rimantadine and amantadine, are currently available for control of this disease. Inactivated vaccine should be given yearly to all of those over the age of 65, as well as younger individuals with high-risk medical conditions and individuals delivering care to such persons. Live, intranasally administered attenuated influenza vaccines are also in development, and may be useful in combination with inactivated vaccine in the elderly. The antiviral drugs amantadine and rimantadine are effective in the treatment and prevention of influenza A, although rimantadine is associated with fewer side-effects. Recently, the inhaled neuraminidase inhibitor zanamivir, which is active against both influenza A and B viruses, was licensed for use in uncomplicated influenza. The role of this drug in treatment and prevention of influenza in the elderly remains to be determined. Additional neuraminidase inhibitors are also being developed. In addition, to influenza, respiratory infections with respiratory syncytial virus, parainfluenza virus, rhinovirus, and coronavirus have been identified as potential problems in the elderly. With increasing attention, it is probable that the impact of these infections in this age group will be more extensively documented. Understanding of the immunology and pathogenesis of these infections in elderly adults is in its infancy, and considerable additional work will need to be performed towards development of effective control measures.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.