ArticleBrain pathology (Zurich, Switzerland)2000
Low frequency of SV40, JC and BK polyomavirus sequences in human medulloblastomas, meningiomas and ependymomas.
Article in Brain pathology (Zurich, Switzerland), 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 96 citations in OpenAlex.
- Rodent models of tumours of the central nervous system.Molecular oncology · 2024Review
- Case-control study: Unveiling human polyomaviruses and papillomavirus in Egyptian colorectal cancer patients.PloS one · 2024Article
- The biology of ependymomas and emerging novel therapies.Nature reviews. Cancer · 2022Review
- Article
- Investigation of simian virus 40 (SV40) and human JC, BK, MC, KI, and WU polyomaviruses in glioma.Journal of neurovirology · 2020Article
- Role of BK human polyomavirus in cancer.Infectious agents and cancer · 2018Review
- Review on the role of the human Polyomavirus JC in the development of tumors.Infectious agents and cancer · 2017Review
- Cancer prevention as biomodulation: targeting the initiating stimulus and secondary adaptations.Annals of the New York Academy of Sciences · 2012Review
- Medulloblastoma-biology and microenvironment: a review.Pediatric hematology and oncology · 2012Review
- Progressive multifocal leukoencephalopathy and promyelocytic leukemia nuclear bodies: a review of clinical, neuropathological, and virological aspects of JC virus-induced demyelinating disease.Acta neuropathologica · 2010Review
- Chronic viral infection and primary central nervous system malignancy.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010Review
- BK virus and human cancer: innocent until proven guilty.Seminars in cancer biology · 2009Review
- Viral regulatory region effects on vertical transmission of polyomavirus SV40 in hamsters.Virology · 2009Article
- Potential mechanisms of the human polyomavirus JC in neural oncogenesis.Journal of neuropathology and experimental neurology · 2008Review
- Involvement of insulin-like growth factor-insulin receptor signal pathway in the transgenic mouse model of medulloblastoma.Cancer science · 2008Article
- High prevalence of human polyomavirus JC VP1 gene sequences in pediatric malignancies.Cellular and molecular biology (Noisy-le-Grand, France) · 2007Article
- Mesothelioma mortality in Europe: impact of asbestos consumption and simian virus 40.Orphanet journal of rare diseases · 2006Article
- Increased p53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused by JC virus.BMC cancer · 2005Article
- Immunolocalization of caveolin-1 in rat and human mesothelium.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2004Article
- Molecular pathogenesis of childhood brain tumors.Journal of neuro-oncology · 2004Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several reports have suggested a role for polyomaviruses in the pathogenesis of human brain tumors. This potential involvement is not conclusively resolved. For the present study, a highly sensitive PCR-assay with fluorescence-labelled primers was developed to search for polyomavirus sequences in human brain tumor and control DNA samples. The assay was shown to detect approximately one viral large T-antigen (TAg) gene per 250 cells. We identified simian virus 40 (SV40)-like sequences in 2/116 medulloblastomas, in 1/131 meningiomas, in 1/25 ependymomas and in 1/2 subependymomas. A single case of ependymoma contained SV40 VP-1 late gene sequences. Moreover, one of the meningioma samples showed JC virus sequences. In contrast, 60 hepatoblastoma samples and 31 brain samples from schizophrenic patients were consistently negative. BK virus sequences were not detectable in any of our samples. Immunohistochemical analysis of two SV40 positive tumor biopsies failed to detect large TAg in the tumor cells. In the JC positive meningioma, immunoreactivity for the viral late gene product (VP-1) was not observed. Our data do not entirely rule out SV40 and JC virus as an initiative agent with a hit-and-run mechanism. However the low frequency of virus sequences and the absence of TAg protein expression argue against a major role of these viruses in the pathogenesis of human medulloblastomas, meningiomas and ependymomas.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.