ArticleEndocrine1999
Expression of prolactin receptor mRNA is increased in the preoptic area of lactating rats.
Article in Endocrine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 38 citations in OpenAlex.
- The neurobiology of parenting and infant-evoked aggression.Physiological reviews · 2025Review
- Hormonal Actions in the Medial Preoptic Area Governing Parental Behavior: Novel Insights From New Tools.Endocrinology · 2024Review
- Effects of Pup Separation on Stress Response in Postpartum Female Rats.International journal of molecular sciences · 2017Article
- Role of Estradiol in the Regulation of Prolactin Secretion During Late Pregnancy.Neurochemical research · 2016Article
- Region-, neuron-, and signaling pathway-specific increases in prolactin responsiveness in reproductively experienced female rats.Endocrinology · 2011Article
- Bridging the gap between GPCR activation and behaviour: oxytocin and prolactin signalling in the hypothalamus.Journal of molecular neuroscience : MN · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated expression of prolactin receptor (PRL-R) mRNA in the preoptic area in midlactating rats compared with diestrous rats. Tissues from specific nuclei were micropunched from 300-microm thick rat brain sections with 300- or 500-microm diameter needles. After total RNA was extracted, the two forms of PRL-R mRNA were evaluated by reverse transcriptase polymerase chain reaction and Southern hybridization. The results showed that levels of long-form PRL-R mRNA in the ventrolateral preoptic nucleus and lateroanterior nucleus in lactating rats were significantly higher (p < 0.05) than in diestrous rats. The ventromedial and medial preoptic nuclei in lactating rats also expressed moderately high levels of long-form mRNA when compared with (p = 0.0547) diestrous rats. The ventromedial and ventrolateral preoptic nuclei, and ventrolateral hypothalamic nucleus in lactating rats expressed significantly higher levels of short-form mRNA than in diestrous rats. The increased expression of both forms of PRL-R mRNA helps explain numerous effects of PRL on brain functions during lactation.
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Registered trials
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