The role of NAC in amyloidogenesis in Alzheimer's disease.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

18 citing papers in PubMed, 46 citations in OpenAlex.

1. Alpha Synuclein Toxicity and Non-Motor Parkinson's.Cells · 2024
   Review
2. Structural and dynamic insights into α-synuclein dimer conformations.Structure (London, England : 1993) · 2023
   Article
3. Copper Binding and Redox Activity of α-Synuclein in Membrane-Like Environment.Biomolecules · 2023
   Article
4. α-Synuclein in synaptic function and dysfunction.Trends in neurosciences · 2023
   Review
5. Functional and Pathological Effects of α-Synuclein on Synaptic SNARE Complexes.Journal of molecular biology · 2023
   Review
6. Characterization of Amyloidogenic Peptide Aggregability in Helical Subspace.Methods in molecular biology (Clifton, N.J.) · 2022
   Article
7. Predictive Modeling of Neurotoxic α-Synuclein Polymorphs.Methods in molecular biology (Clifton, N.J.) · 2022
   Article
8. α-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradox.Cell & bioscience · 2021
   Review
9. Hypobaria-Induced Oxidative Stress Facilitates Homocysteine Transsulfuration and Promotes Glutathione Oxidation in Rats with Mild Traumatic Brain Injury.Journal of central nervous system disease · 2021
   Article
10. Deciphering the Biochemical Pathway and Pharmacokinetic Study of Amyloid βeta-42 with Superparamagnetic Iron Oxide Nanoparticles (SPIONs) Using Systems Biology Approach.Molecular neurobiology · 2018
    Article
11. Familial Mutations May Switch Conformational Preferences in α-Synuclein Fibrils.ACS chemical neuroscience · 2017
    Article
12. Coupling of the non-amyloid-component (NAC) domain and the KTK(E/Q)GV repeats stabilize the α-synuclein fibrils.European journal of medicinal chemistry · 2016
    Article
13. Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner.Scientific reports · 2015
    Article
14. The many faces of α-synuclein: from structure and toxicity to therapeutic target.Nature reviews. Neuroscience · 2013
    Review
15. Neuropathological alterations in Alzheimer disease.Cold Spring Harbor perspectives in medicine · 2011
    Review
16. Role of synucleins in Alzheimer's disease.Neurotoxicity research · 2009
    Article
17. Lack of alpha-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease.Molecular neurodegeneration · 2007
    Article
18. Cross-seeding of alpha-synuclein aggregation by amyloid fibrils of food proteins.The Journal of biological chemistry
    Article

Corrections and comments

• Comment on
  Non-Abeta component of Alzheimer's disease amyloid (NAC) revisited. NAC and alpha-synuclein are not associated with Abeta amyloid.1999

Authors and funding

5 authors at 4 institutions in 4 countries.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as