ArticleOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life1999
Clay catalysis of oligonucleotide formation: kinetics of the reaction of the 5'-phosphorimidazolides of nucleotides with the non-basic heterocycles uracil and hypoxanthine.
Article in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 61 citations in OpenAlex.
- Review
- Life on Minerals: Binding Behaviors of Oligonucleotides on Zirconium Silicate and Its Inhibitory Activity for the Self-Cleavage of Hammerhead Ribozyme.Life (Basel, Switzerland) · 2022Article
- The origin of biological homochirality along with the origin of life.PLoS computational biology · 2020Article
- Walking over 4 Gya: Chemical Evolution from Photochemistry to Mineral and Organic Chemistries Leading to an RNA World.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2017Review
- Nitrogenous Derivatives of Phosphorus and the Origins of Life: Plausible Prebiotic Phosphorylating Agents in Water.Life (Basel, Switzerland) · 2017Review
- The origin of life is a spatially localized stochastic transition.Biology direct · 2012Article
- Prebiotically plausible mechanisms increase compositional diversity of nucleic acid sequences.Nucleic acids research · 2012Article
- The origins of the RNA world.Cold Spring Harbor perspectives in biology · 2012Review
- Homochiral selectivity in RNA synthesis: montmorillonite-catalyzed quaternary reactions of D, L-purine with D, L- pyrimidine nucleotides.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2011Article
- Influence of montmorillonite on nucleotide oligomerization reactions: a molecular dynamics study.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2010Article
- Kinetic analysis of oligo(C) formation from the 5'-monophosphorimidazolide of cytidine with Pb(II) ion catalyst at 10-75 degrees C.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2007Article
- Montmorillonite-catalysed formation of RNA oligomers: the possible role of catalysis in the origins of life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The montmorillonite clay catalyzed condensation of activated monocleotides to oligomers of RNA is a possible first step in the formation of the proposed RNA world. The rate constants for the condensation of the phosphorimidazolide of adenosine were measured previously and these studies have been extended to the phosphorimidazolides of inosine and uridine in the present work to determine of substitution of neutral heterocycles for the basic adenine ring changes the reaction rate or regioselectivity. The oligomerization reactions of the 5'-phosphoromidazolides of uridine (ImpU) and inosine (ImpI) on montmorillonite yield oligo(U)s and oligo(I)s as long as heptamers. The rate constants for oligonucleotide formation were determined by measuring the rates of formation of the oligomers by HPLC. Both the apparent rate constants in the reaction mixture and the rate constants on the clay surface were calculated using the partition coefficients of the oligomers between the aqueous and clay phases. The rate constants for trimer formation are much greater than those dimer synthesis but there was little difference in the rate constants for the formation of trimers and higher oligomers. The overall rates of oligomerization of the phosphorimidazolides of purine and pyrimidine nucleosides in the presence of montmorillonite clay are the same suggesting that RNA formed on the primitive Earth could have contained a variety of heterocyclic bases. The rate constants for oligomerization of pyrimidine nucleotides on the clay surface are significantly higher than those of purine nucleotides since the pyrimidine nucleotides bind less strongly to the clay than do the purine nucleotides. The differences in the binding is probably due to Van der Waals interactions between the purine bases and the clay surface. Differences in the basicity of the heterocyclic ring in the nucleotide have little effect on the oligomerization process.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.