ArticleNucleic acids research2000
Protein sequences conserved in prokaryotic aminoacyl-tRNA synthetases are important for the activity of the processivity factor of human mitochondrial DNA polymerase.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 49 citations in OpenAlex.
- Interference with mitochondrial metabolism could serve as a potential therapeutic strategy for advanced prostate cancer.PloS one · 2024Article
- Structure-specific roles for PolG2-DNA complexes in maintenance and replication of mitochondrial DNA.Nucleic acids research · 2023Article
- Structural and Molecular Basis for Mitochondrial DNA Replication and Transcription in Health and Antiviral Drug Toxicity.Molecules (Basel, Switzerland) · 2023Review
- Exploiting a Y chromosome-linked Cas9 for sex selection and gene drive.Nature communications · 2021Article
- Article
- RNA Rings Strengthen Hairpin Accretion Hypotheses for tRNA Evolution: A Reply to Commentaries by Z.F. Burton and M. Di Giulio.Journal of molecular evolution · 2020Article
- Biochemical analysis of human POLG2 variants associated with mitochondrial disease.Human molecular genetics · 2011Article
- Structural insight on processivity, human disease and antiviral drug toxicity.Current opinion in structural biology · 2011Review
- Late-onset ptosis and myopathy in a patient with a heterozygous insertion in POLG2.Journal of neurology · 2010Article
- A mechanistic view of human mitochondrial DNA polymerase gamma: providing insight into drug toxicity and mitochondrial disease.Biochimica et biophysica acta · 2010Review
- The EM structure of human DNA polymerase gamma reveals a localized contact between the catalytic and accessory subunits.The EMBO journal · 2007Article
- Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia.American journal of human genetics · 2006Article
- A novel processive mechanism for DNA synthesis revealed by structure, modeling and mutagenesis of the accessory subunit of human mitochondrial DNA polymerase.Journal of molecular biology · 2006Article
- The mitochondrial DNA polymerase as a target of oxidative damage.Nucleic acids research · 2002Article
- The accessory subunit of DNA polymerase gamma is essential for mitochondrial DNA maintenance and development in Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine.Molecular and cellular biology · 2002Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies have shown that the small subunit of Xenopus DNA polymerase gamma (pol gammaB) acts as a processivity factor to stimulate the 140 kDa catalytic subunit of human DNA polymerase gamma. A putative human pol gammaB initially identified by analysis of DNA sequence had not been shown to be functional, and appeared to be an incomplete clone. In this paper, we report the cloning of full-length human and mouse pol gammaB. Both human and mouse pol gammaB proteins were expressed in their mature forms, without their apparent mitochondrial localization signals, and shown to stimulate processivity of the recombinant catalytic subunit of human pol gammaA. Deletion analysis of human pol gammaB indicated that blocks of sequence conserved with prokaryotic class II aminoacyl-tRNA synthetases are necessary for activity and inter-action with human pol gammaA. Purification of DNA pol gamma from HeLa cells indicated that both proteins are associated in vivo.
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