ArticleNucleic acids research2000
Regulation of double-strand break-induced mammalian homologous recombination by UBL1, a RAD51-interacting protein.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 71 citations in OpenAlex.
- TOPORS-mediated RAD51 SUMOylation facilitates homologous recombination repair.Nucleic acids research · 2022Article
- Advances in SUMO-based regulation of homologous recombination.Current opinion in genetics & development · 2021Review
- Depletion of DNA damage binding protein 2 sensitizes triple-negative breast cancer cells to poly ADP-ribose polymerase inhibition by destabilizing Rad51.Cancer science · 2019Article
- Sumoylation-independent activation of Calcineurin-NFAT-signaling via SUMO2 mediates cardiomyocyte hypertrophy.Scientific reports · 2016Article
- Small ubiquitin-like modifier (SUMO) isoforms and conjugation-independent function in DNA double-strand break repair pathways.The Journal of biological chemistry · 2014Article
- Role of Cdc48/p97 as a SUMO-targeted segregase curbing Rad51-Rad52 interaction.Nature cell biology · 2013Article
- Manganese superoxide dismutase interacts with a large scale of cellular and mitochondrial proteins in low-dose radiation-induced adaptive radioprotection.Free radical biology & medicine · 2012Article
- SUMO and SUMOylation in plants.Molecules and cells · 2011Review
- Transcriptional Suppression by Transient Recruitment of ARIP4 to Sumoylated nuclear receptor Ad4BP/SF-1.Molecular biology of the cell · 2009Article
- SUMO1 negatively regulates BRCA1-mediated transcription, via modulation of promoter occupancy.Nucleic acids research · 2008Article
- SUMO junction-what's your function? New insights through SUMO-interacting motifs.EMBO reports · 2007Review
- Role of SUMO/Ubc9 in DNA damage repair and tumorigenesis.Journal of molecular histology · 2006Article
- SUMO-1 represses apoptosis signal-regulating kinase 1 activation through physical interaction and not through covalent modification.EMBO reports · 2005Article
- The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair.Molecular and cellular biology · 2005Article
- Article
- A new Saccharomyces cerevisiae strain with a mutant Smt3-deconjugating Ulp1 protein is affected in DNA replication and requires Srs2 and homologous recombination for its viability.Molecular and cellular biology · 2004Article
- SUMO: a regulator of gene expression and genome integrity.Oncogene · 2004Review
- Review
- DNA-dependent protein kinase suppresses double-strand break-induced and spontaneous homologous recombination.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Overexpression of human RAD51 and RAD52 reduces double-strand break-induced homologous recombination in mammalian cells.Nucleic acids research · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Mammalian RAD51 protein plays essential roles in DNA homologous recombination, DNA repair and cell proliferation. RAD51 activities are regulated by its associated proteins. It was previously reported that a ubiquitin-like protein, UBL1, associates with RAD51 in the yeast two-hybrid system. One function of UBL1 is to covalently conjugate with target proteins and thus modify their function. In the present study we found that non-conjugated UBL1 forms a complex with RAD51 and RAD52 proteins in human cells. Overexpression of UBL1 down-regulates DNA double-strand break-induced homologous recombination in CHO cells and reduces cellular resistance to ionizing radiation in HT1080 cells. With or without overexpressed UBL1, most homologous recombination products arise by gene conversion. However, overexpression of UBL1 reduces the fraction of bidirectional gene conversion tracts. Overexpression of a mutant UBL1 that is incapable of being conjugated retains the ability to inhibit homologous recombination. These results suggest a regulatory role for UBL1 in homologous recombination.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.