ArticleThe American journal of pathology2000
Comparative genomic hybridization reveals frequent losses of chromosomes 1p and 3q in pheochromocytomas and abdominal paragangliomas, suggesting a common genetic etiology.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 113 citations in OpenAlex.
- Manipulating mitochondrial electron flow enhances tumor immunogenicity.Science (New York, N.Y.) · 2023Article
- Comprehensive Genetic Study of Malignant Cervical Paraganglioma.International journal of molecular sciences · 2023Article
- SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB/NF1 loss yields SDHx-like pheochromocytomas.Cell reports · 2022Article
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- Article
- Composite tumor with pheochromocytoma and immature neuroblastoma: report of two cases with cytogenetic analysis and discussion of current terminology.Virchows Archiv : an international journal of pathology · 2017Article
- Paraganglioma of the bladder in a kidney transplant recipient: A case report.Molecular and clinical oncology · 2017Article
- Loss of maternal chromosome 11 is a signature event in SDHAF2, SDHD, and VHL-related paragangliomas, but less significant in SDHB-related paragangliomas.Oncotarget · 2017Article
- Neuroendocrine Tumors of the Urinary Bladder According to the 2016 World Health Organization Classification: Molecular and Clinical Characteristics.Endocrine pathology · 2016Review
- Phenylethanolamine N-methyltransferase downregulation is associated with malignant pheochromocytoma/paraganglioma.Oncotarget · 2016Article
- Review
- Profiling of somatic mutations in phaeochromocytoma and paraganglioma by targeted next generation sequencing analysis.International journal of endocrinology · 2015Article
- Adrenal medullary hyperplasia is a precursor lesion for pheochromocytoma in MEN2 syndrome.Neoplasia (New York, N.Y.) · 2014Article
- Rare germline mutations identified by targeted next-generation sequencing of susceptibility genes in pheochromocytoma and paraganglioma.The Journal of clinical endocrinology and metabolism · 2014Article
- Copy number alterations in small intestinal neuroendocrine tumors determined by array comparative genomic hybridization.BMC cancer · 2013Article
- Molecular and therapeutic advances in the diagnosis and management of malignant pheochromocytomas and paragangliomas.The oncologist · 2013Review
- Malignant pheochromocytomas and paragangliomas: a diagnostic challenge.Langenbeck's archives of surgery · 2012Review
- Molecular cytogenetic characterization in four pediatric pheochromocytomas and paragangliomas.Pathology oncology research : POR · 2011Article
- SDHA is a tumor suppressor gene causing paraganglioma.Human molecular genetics · 2010Article
- SDH mutations in tumorigenesis and inherited endocrine tumours: lesson from the phaeochromocytoma-paraganglioma syndromes.Journal of internal medicine · 2009Review
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pheochromocytomas and abdominal paragangliomas are rare, catecholamine-producing tumors that arise from the chromaffin cells derived from the neural crest. We used comparative genomic hybridization (CGH) to screen for copy number changes in 23 pheochromocytomas and 11 abdominal paragangliomas. The pattern of copy number changes was similar between pheochromocytomas and paragangliomas, with the most consistent finding being loss of 1cen-p31, which was detected in 28/34 tumors (82%). Losses were also found on 3q22-25 (41%), 11p (26%), 3p13-14 (24%), 4q (21%), 2q (15%), and 11q22-23 (15%), and gains were detected on 19p (26%), 19q (24%), 17q24-qter (21%), 11cen-q13 (15%), and 16p (15%). Losses of 1p and 3q were detected in the majority of tumors, whereas gains of 19p and q, 17q, and 16p were seen only in tumors with six or more CGH alterations. This progression of genetic events did not correspond with the conversion to a malignant phenotype. CGH alterations involving chromosome 11 were more frequent in the malignant tumors, compared with the benign tumors (9/12 versus 3/16). In summary, we propose that pheochromocytomas and abdominal paragangliomas, which share many clinical features, also have a common genetic origin and that the loss of 1cen-p31 represents an early and important event in tumor development.
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