ArticleThe American journal of pathology2000
Liver regeneration in rats with retrorsine-induced hepatocellular injury proceeds through a novel cellular response.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
48 citing papers in PubMed, 191 citations in OpenAlex.
- Retrorsine impairs liver regeneration by inducing progenitor cell-senescenceAnnals of medicine · 2026Article
- Microbiome-derived bile acids as endogenous regenerative mediators in liver repair.Regenerative therapy · 2025Review
- "Small Hepatocytes" in the Liver.Cells · 2023Review
- Distinct hepatocyte identities in liver homeostasis and regeneration.JHEP reports : innovation in hepatology · 2023Review
- CINC-2 and miR-199a-5p in EVs secreted by transplanted Thy1Stem cell research & therapy · 2023Article
- In vitro proliferation and long-term preservation of functional primary rat hepatocytes in cell fibers.Scientific reports · 2022Article
- Functional products fortified with probiotic LAB isolated from Egyptian dairy sources showed hypolipidemic effects in Albino rats.PloS one · 2022Article
- Isolation of Small Hepatocyte-Like Progenitor Cells from Retrorsine/Partial Hepatectomy Rat Livers by Laser Microdissection.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Extracellular vesicles containing miR-146a-5p secreted by bone marrow mesenchymal cells activate hepatocytic progenitors in regenerating rat livers.Stem cell research & therapy · 2021Article
- Nano-encapsulated Iron and Folic Acid-Fortified Functional Yogurt Enhance Anemia in Albino Rats.Frontiers in nutrition · 2021Article
- Cell competition in liver carcinogenesis.World journal of hepatology · 2020Review
- A Pre-Clinical Large Animal Model of Sustained Liver Injury and Regeneration Stimulus.Scientific reports · 2018Article
- Small hepatocyte-like progenitor cells may be a Hedgehog signaling pathway-controlled subgroup of liver stem cells.Experimental and therapeutic medicine · 2016Article
- Hepatic stellate cells contribute to progenitor cells and liver regeneration.The Journal of clinical investigation · 2014Article
- Role of liver stem cells in hepatocarcinogenesis.World journal of stem cells · 2014Review
- Comparison of the liver function and hepatic specific genes expression in cultured mesenchymal stem cells and hepatocytes.Iranian journal of basic medical sciences · 2014Article
- Role of stem cells in repair of liver injury: experimental and clinical benefit of transferred stem cells on liver failure.World journal of gastroenterology · 2013Review
- Polyploidization without mitosis improves in vivo liver transduction with lentiviral vectors.Human gene therapy · 2013Article
- Article
- Activation of inactive hepatocytes through histone acetylation: a mechanism for functional compensation after massive loss of hepatocytes.The American journal of pathology · 2011Article
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4 authors at 3 institutions in 1 country.
Funding
Abstract
The adult rodent liver contains at least two recognized populations of cells with stem-like properties that contribute to liver repair/regeneration under different pathophysiological circumstances: (i) unipotential committed progenitor cells (differentiated hepatocytes and biliary epithelial cells) and (ii) multipotential nonparenchymal progenitor cells (oval cells). In retrorsine-induced hepatocellular injury the capacity of fully differentiated rat hepatocytes to replicate is severely impaired and massive proliferation of oval cells does not occur. Nevertheless, retrorsine-exposed rats can replace their entire liver mass after 2/3 surgical partial hepatectomy through the emergence and expansion of a population of small hepatocyte-like progenitor cells that expresses phenotypic characteristics of fetal hepatoblasts, oval cells, and fully differentiated hepatocytes, but differ distinctly from each type of cell. The activation, proliferation, and complete regeneration of normal liver structure from small hepatocyte-like progenitor cells have not been recognized in other models of liver injury characterized by impaired hepatocyte replication. We suggest that the selective emergence and expansion of small hepatocyte-like progenitor cells observed in the retrorsine model reflect a novel mechanism of complete liver regeneration in the adult rat. Furthermore, we suggest that these cells may represent a novel progenitor cell population that (i) responds to liver deficit when the replication capacity of differentiated hepatocytes is impaired, (ii) expresses an extensive proliferative capacity, (iii) can give rise to large numbers of progeny hepatocytes, and (iv) can restore tissue mass.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.