ArticleThe American journal of pathology2000
Microsatellite instability in gastric intestinal metaplasia in patients with and without gastric cancer.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Microsatellite instable early gastric cancers; a distinct molecular profile with HER2 over-expression and increased multiple lesion risk.BMC gastroenterology · 2026Article
- Case Report: Successful treatment of mismatch repair-deficient cervical esophageal adenocarcinoma with immune checkpoint inhibition.Frontiers in oncology · 2026Article
- Knowledge-guided adaptation of pathology foundation models effectively improves cross-domain generalization and demographic fairness.Nature communications · 2025Article
- Gastric Cancer after <italic>Helicobacter pylori</italic> Eradication: Characteristics, Diagnosis, and Management.Digestion · 2025Review
- Review
- The role of gastric microecological dysbiosis in gastric carcinogenesis.Frontiers in microbiology · 2023Review
- High Frequency of Microsatellite Instability among Non-Metastatic Gastric Cancer.International journal of hematology-oncology and stem cell research · 2022Article
- Clinical outcomes of metachronous recurrence of gastric epithelial neoplasia based on Helicobacter pylori infection status and microsatellite stability.The Korean journal of internal medicine · 2022Article
- Molecular alterations in gastric cancer and the surrounding intestinal metaplastic mucosa: an analysis of isolated glands.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2021Article
- How Should We Test for Lynch Syndrome? A Review of Current Guidelines and Future Strategies.Cancers · 2021Review
- Intervention effects of lotus leaf flavonoids on gastric mucosal lesions in mice infected withRSC advances · 2020Article
- Aberrant DNA Polymerase Beta EnhancesCancers · 2019Article
- Microsatellite Instability and Altered Expressions of MLH1 and MSH2 in Gastric CancerAsian Pacific journal of cancer prevention : APJCP · 2019Article
- Personalized risk assessment for dynamic transition of gastric neoplasms.Journal of biomedical science · 2018Article
- PositiveOncotarget · 2017Article
- PostoperativeGut and liver · 2017Article
- Risk factors for intestinal metaplasia in a southeastern Chinese population: an analysis of 28,745 cases.Journal of cancer research and clinical oncology · 2017Article
- Diagnostic, Predictive, Prognostic, and Therapeutic Molecular Biomarkers in Third Millennium: A Breakthrough in Gastric Cancer.BioMed research international · 2017Review
- Gastric biomarkers: a global review.World journal of surgical oncology · 2016Review
- High-definition CpG methylation of novel genes in gastric carcinogenesis identified by next-generation sequencing.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The role and significance of microsatellite instability (MSI) in gastric carcinogenesis remain unknown. This study determined the chronology of MSI in gastric carcinogenesis by examining intestinal metaplasia (IM) from patients with and without gastric cancer. DNA was obtained from gastric specimens of 75 patients with gastric IM (30 cancer, 26 peptic ulcer, and 19 chronic gastritis patients) and was amplified with a set of eight microsatellite markers. Eight (26. 7%) tumors and seven (9.3%) IM samples (three from cancer-free patients) displayed high-level MSI (three or more loci altered). Low-level MSI (one or two loci altered) was detected in 50% of the tumors, in 40% of IM samples coexisting with cancer, and in 38% of IM tissues of cancer-free individuals. Among the 30 cancer patients, microsatellites were more frequently altered in IM coexisting with tumors that showed MSI (P = 0.003). In addition, patients with low-level MSI in the tumor tissues were more likely to have active Helicobacter pylori infection than those with stable tumors (P = 0.02). In conclusion, this study indicates that MSI occurs not only in gastric IM of patients with gastric carcinoma, but also in IM of cancer-free individuals. These data suggest that the progressive accumulation of MSI in areas of IM may contribute to gastric cancer development, representing an important molecular event in the multistep gastric carcinogenesis cascade.
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