ArticleJournal of virology2000
Sint1, a common integration site in SL3-3-induced T-cell lymphomas, harbors a putative proto-oncogene with homology to the septin gene family.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 43 citations in OpenAlex.
- The Roles of Septins in Regulating Fission Yeast Cytokinesis.Journal of fungi (Basel, Switzerland) · 2024Review
- Proteomic profiling of the oncogenic septin 9 reveals isoform-specific interactions in breast cancer cells.Proteomics · 2021Article
- Structure and function of Septin 9 and its role in human malignant tumors.World journal of gastrointestinal oncology · 2020Review
- Septin Mutations in Human Cancers.Frontiers in cell and developmental biology · 2016Review
- Septin 9 isoform expression, localization and epigenetic changes during human and mouse breast cancer progression.Breast cancer research : BCR · 2011Article
- Conquering the complex world of human septins: implications for health and disease.Clinical genetics · 2010Review
- Antisense transcription in gammaretroviruses as a mechanism of insertional activation of host genes.Journal of virology · 2010Article
- Article
- Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility.Nature cell biology · 2009Article
- Characterization of a SEPT9 interacting protein, SEPT14, a novel testis-specific septin.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Activation of an oncogenic microRNA cistron by provirus integration.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Do septins have a role in cancer?British journal of cancer · 2005Review
- Multimodality expression profiling shows SEPT9 to be overexpressed in a wide range of human tumours.Oncogene · 2005Article
- The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis.Molecular biology of the cell · 2002Article
- Fusion of MLL and MSF in adult de novo acute myelomonocytic leukemia (M4) with t(11;17)(q23;q25).International journal of hematology · 2002Article
- Disruption of hematopoiesis and thymopoiesis in the early premalignant stages of infection with SL3-3 murine leukemia virus.Journal of virology · 2002Article
- Genomic organization, complex splicing pattern and expression of a human septin gene on chromosome 17q25.3.Oncogene · 2001Article
- Identification of Notch1 as a frequent target for provirus insertional mutagenesis in T-cell lymphomas induced by leukemogenic mutants of mouse mammary tumor virus.Journal of virology · 2000Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The murine retrovirus SL3-3 is a potent inducer of T-cell lymphomas when inoculated into susceptible newborn mice. Previously, DNAs from twenty SL3-3-induced tumors were screened by PCR for provirus integration sites. Two out of 20 tumors demonstrated clonal provirus insertion into a common region. This region has now been isolated and characterized. The region, named SL3-3 integration site 1 (Sint1), maps to the distal end of mouse chromosome 11, corresponding to human chromosome 17q25, and may be identical to a mouse mammary tumor virus integration site in a T-cell lymphoma, Pad3. Two overlapping genomic lambda clones spanning about 35 kb were isolated and used as a starting point for a search for genes in the neighborhood of the virus integration sites. A genomic fragment was used as a hybridization probe to isolate a 3-kb cDNA clone, the expression of which was upregulated in one of two tumors harboring a provirus in Sint1. The cDNA clone is predicted to encode a protein which shows 97.0% identity to a human septin-like protein encoded by a gene which has been found as a fusion partner gene of MLL in an acute myeloid leukemia with a t(11;17)(q23;q25). Together these findings raise the possibility that a proto-oncogene belonging to the septin family, and located about 15 kb upstream of the provirus integration sites, is involved in murine leukemia virus-induced T-cell lymphomagenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.