ArticleThe Plant cell2000
The role of AHA motifs in the activator function of tomato heat stress transcription factors HsfA1 and HsfA2.
Article in The Plant cell, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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Who cites it
90 citing papers in PubMed.
- A Heat-Inducible Rubisco Activase Safeguards Photosynthesis via Multilevel Regulation and Dual Function.Plant biotechnology journal · 2026Article
- Genome-wide identification of Hsf gene family in citrus and functional analysis of CsHsfA1a in heat stress response.Plant cell reports · 2026Article
- Integrative characterization of the heat shock transcription factors inFrontiers in plant science · 2026Article
- Genome-Wide Analysis ofFood science & nutrition · 2026Article
- Promoter and domain swap analysis delineates heat stress memory-specific determinants of heat shock factor HSFA2.Plant physiology · 2025Article
- Article
- Characterization of the heat shock factor RcHsfA6 in Rosa chinensis and function in the thermotolerance of Arabidopsis.BMC plant biology · 2025Article
- A Heat-Shock Transcription Factor inInternational journal of molecular sciences · 2025Article
- Computationally derived RNA polymerase III promoters enable maize genome editing.Frontiers in plant science · 2025Article
- Genome-wide characterization of theFrontiers in plant science · 2025Article
- Genome-Wide Identification and Expression Analysis of theCurrent issues in molecular biology · 2024Article
- Genome-wide identification, phylogeny and expression analysis of Hsf gene family in Verbena bonariensis under low-temperature stress.BMC genomics · 2024Article
- Deleterious Effects of Heat Stress on the Tomato, Its Innate Responses, and Potential Preventive Strategies in the Realm of Emerging Technologies.Metabolites · 2024Review
- Genome-Wide Analysis of theBiology · 2024Article
- A Genome-Wide Analysis and Expression Profile of Heat Shock Transcription Factor (Hsf) Gene Family inPlants (Basel, Switzerland) · 2023Article
- HSF and Hsp Gene Families in sunflower: a comprehensive genome-wide determination survey and expression patterns under abiotic stress conditions.Protoplasma · 2023Article
- Genome-Wide Identification ofInternational journal of molecular sciences · 2023Article
- Evolutionary Consequences of Functional and Regulatory Divergence of HD-Zip I Transcription Factors as a Source of Diversity in Protein Interaction Networks in Plants.Journal of molecular evolution · 2023Review
- Thermosensitive SUMOylation of TaHsfA1 defines a dynamic ON/OFF molecular switch for the heat stress response in wheat.The Plant cell · 2023Article
- Characterization of the Heat Shock Transcription Factor Family inInternational journal of molecular sciences · 2023Article
30 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using reporter assays in tobacco protoplasts and yeast, we investigated the function of the acidic C-terminal activation domains of tomato heat stress transcription factors HsfA1 and HsfA2. Both transcription factors contain short, essential peptide motifs with a characteristic pattern of aromatic and large hydrophobic amino acid residues embedded in an acidic context (AHA motifs). The prototype is the AHA1 motif of HsfA2, which has the sequence DDIWEELL. Our mutational analysis supports the important role of the aromatic and large hydrophobic amino acid residues in the core positions of the AHA motifs. The pattern suggests the formation of an amphipathic, negatively charged helix as the putative contact region with components of the basal transcription complex. In support of this concept, proline or positively charged residues in or adjacent to the AHA motifs markedly reduce or abolish their activity. Both AHA motifs of HsfA1 and HsfA2 contribute to activator potential, and they can substitute for each other; however, there is evidence for sequence and positional specificity.
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10662862PMC139763What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.