ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Stabilization of growing retinal axons by the combined signaling of nitric oxide and brain-derived neurotrophic factor.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
30 citing papers in PubMed, 108 citations in OpenAlex.
- Intrinsic organization of the corpus callosum.Frontiers in physiology · 2024Review
- Target-selective vertebrate motor axon regeneration depends on interaction with glial cells at a peripheral nerve plexus.PLoS biology · 2023Article
- A glia cell dependent mechanism at a peripheral nerve plexus critical for target-selective axon regeneration.bioRxiv : the preprint server for biology · 2023Article
- Transcriptome analysis in mice treated with vigabatrin identifies dysregulation of genes associated with retinal signaling circuitry.Epilepsy research · 2020Article
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- BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity.Cellular and molecular neurobiology · 2018Review
- Uncovering the regeneration strategies of zebrafish organs: a comprehensive systems biology study on heart, cerebellum, fin, and retina regeneration.BMC systems biology · 2018Article
- Article
- Article
- BDNF-induced nitric oxide signals in cultured rat hippocampal neurons: time course, mechanism of generation, and effect on neurotrophin secretion.Frontiers in cellular neuroscience · 2014Article
- Mitochondrial Dynamics in Retinal Ganglion Cell Axon Regeneration and Growth Cone Guidance.Journal of ocular biology · 2013Article
- NO orchestrates the loss of synaptic boutons from adult "sick" motoneurons: modeling a molecular mechanism.Molecular neurobiology · 2011Review
- Nitric oxide synthase regulates morphogenesis of zebrafish spinal cord motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Analysis of the astray/robo2 zebrafish mutant reveals that degenerating tracts do not provide strong guidance cues for regenerating optic axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Spinal motoneuron synaptic plasticity after axotomy in the absence of inducible nitric oxide synthase.Journal of neuroinflammation · 2010Article
- Kinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array.The Journal of cell biology · 2007Article
- Effect of peripheral axotomy on gene expression of NIDD in rat neural tissues.Journal of molecular neuroscience : MN · 2007Article
- Developmental regulation of sensory axon regeneration in the absence of growth cones.Journal of neurobiology · 2006Article
- Signaling from blood vessels to CNS axons through nitric oxide.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- RhoA-kinase and myosin II are required for the maintenance of growth cone polarity and guidance by nerve growth factor.Journal of neurobiology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The pattern of axonal projections early in the development of the nervous system lacks the precision present in the adult. During a developmental process of refinement, mistargeted projections are eliminated while correct projections are retained. Previous studies suggest that during development nitric oxide (NO) is involved in the elimination of mistargeted retinal axons, whereas brain-derived neurotrophic factor (BDNF) may stabilize retinal axon arbors. It is unclear whether these neuromodulators interact. This study showed that NO induced growth cone collapse and retraction of developing retinal axons. This effect was not attributable to NO-induced neurotoxicity. BDNF protected growth cones and axons from the effects of NO. This effect was specific to BDNF, because neither nerve growth factor (NGF) nor neurotrophin-3 (NT-3) prevented NO-induced growth cone collapse and axon retraction. Exposure to both BDNF and NO, but not either factor alone, stabilized growth cones and axons. Stabilized axons exhibited minimal retraction or extension. This response appears to be a new axon "state" and not simply a partial amelioration of the effect of NO, because lower doses of BDNF or NO allowed axon extension. Furthermore, BDNF/NO-induced growth cone stabilization correlated with the appearance of a cytochalasin D-resistant population of actin filaments. BDNF protection from NO likely was mediated locally at the level of the growth cone, because growth cones or individual filopodia in contact with BDNF-coated beads were protected from NO-induced collapse. These findings suggest a cellular mechanism by which some axonal connections are stabilized and some are eliminated during development.
Indexed as
Identifiers
10662836PMC6772364W1647008873What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.