ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Molecular cloning and functional expression of the potassium-dependent sodium-calcium exchanger from human and chicken retinal cone photoreceptors.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 88 citations in OpenAlex.
- Structural and functional mapping of ion access pathways in the human KChannels (Austin, Tex.) · 2025Article
- Regulation of KInternational journal of molecular sciences · 2022Review
- Biochemistry and physiology of zebrafish photoreceptors.Pflugers Archiv : European journal of physiology · 2021Review
- Regulation of calcium homeostasis in the outer segments of rod and cone photoreceptors.Progress in retinal and eye research · 2018Review
- Investigating the CaScientific reports · 2018Article
- The NaeLife · 2017Article
- Article
- The Na(+)/Ca(2+), K(+) exchanger 2 modulates mammalian cone phototransduction.Scientific reports · 2016Article
- Identification of the neuromuscular junction transcriptome of extraocular muscle by laser capture microdissection.Investigative ophthalmology & visual science · 2010Article
- Residues contributing to the Na(+)-binding pocket of the SLC24 Na(+)/Ca(2+)-K(+) Exchanger NCKX2.The Journal of biological chemistry · 2010Article
- How vision begins: an odyssey.Proceedings of the National Academy of Sciences of the United States of America · 2008Review
- A critical role for the potassium-dependent sodium-calcium exchanger NCKX2 in protection against focal ischemic brain damage.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- A typology of photoreceptor gene expression patterns in the mouse.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Searching for a role of NCX/NCKX exchangers in neurodegeneration.Molecular neurobiology · 2007Review
- Functional characterization and molecular cloning of the K+-dependent Na+/Ca2+ exchanger in intact retinal cone photoreceptors.The Journal of general physiology · 2007Article
- Serca isoform expression in the mammalian retina.Experimental eye research · 2005Article
- The SLC24 Na+/Ca2+-K+ exchanger family: vision and beyond.Pflugers Archiv : European journal of physiology · 2004Review
- Distribution of K+-dependent Na+/Ca2+ exchangers in the rat supraoptic magnocellular neuron is polarized to axon terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Calcium regulation in photoreceptors.Frontiers in bioscience : a journal and virtual library · 2002Review
- K+-dependent Na+/Ca2+ exchange is a major Ca2+ clearance mechanism in axon terminals of rat neurohypophysis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Light causes a rapid lowering of cytosolic free calcium in the outer segments of both retinal rod and cone photoreceptors. This light-induced lowering of calcium is caused by extrusion via a Na-Ca exchanger located in the rod and cone outer segment plasma membrane and plays a key role in the process of light adaptation. The Na-Ca exchanger in retinal rod outer segment was shown earlier to be a novel Na-Ca+K exchanger (NCKX), and its cDNA was obtained by molecular cloning from several mammalian species. On the other hand, the proper identity of the retinal cone Na-Ca exchanger, in terms of both functional characteristics (e.g., requirement for and transport of potassium) and molecular identity, has not yet been elucidated. Here, we report the molecular cloning, intraretinal localization by in situ hybridization, and initial functional characterization of the chicken and human cone-specific Na-Ca exchangers. In addition we report the chicken rod-specific NCKX. We identified NCKX transcripts in both human and chicken cones and observed strong potassium-dependent Na-Ca exchange activity after heterologous expression of human and chicken cone NCKX cDNAs in cultured insect cells. In situ hybridization in chicken retina showed abundant rod NCKX transcripts only in rod photoreceptors, whereas abundant cone NCKX transcripts were found in most, if not all, cone photoreceptors and also in a subpopulation of retinal ganglion cells. A detailed comparison with the previously described retinal rod and brain NCKX cDNAs is presented.
Indexed as
Identifiers
10662833PMC6772386W1605764426What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.