ArticleThe Histochemical journal1999
Stromelysin-1 (MMP-3) in forming enamel and predentine in rat incisor-coordinated distribution with proteoglycans suggests a functional role.
Article in The Histochemical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 91 citations in OpenAlex.
- Allelic and Genotypic Distribution ofClinics and practice · 2025Article
- MMP-9 expression in rat pup incisor teeth is not altered by maternal hypertension or maternal atenolol treatment during pregnancy and lactation.Journal of molecular histology · 2024Article
- Matrix metalloproteinase inhibitors in restorative dentistry.Journal of conservative dentistry and endodontics · 2024Review
- Targeting Matrix Metalloproteinase-3 for Dental Caries Prevention Using Herbal Isolates: MMP3 Inhibition by Cinnamic Acids.International journal of dentistry · 2024Article
- Tooth ultrastructure changes induced by a nonsense mutation in the FAM83H gene: insights into the diversity of amelogenesis imperfecta.Clinical oral investigations · 2023Article
- Expression of matrix metalloproteinase-3 and -10 is up-regulated in the periodontal tissues of aged mice.Journal of periodontal research · 2022Article
- Dentine matrix metalloproteinases as potential mediators of dentine regeneration.European cells & materials · 2021Review
- A Potential Role for MMPs during the Formation of Non-Neurogenic Placodes.Journal of developmental biology · 2018Review
- DENTAL ENAMEL FORMATION AND IMPLICATIONS FOR ORAL HEALTH AND DISEASE.Physiological reviews · 2017Review
- [Progress on matrix metalloproteinase inhibitors].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2017Article
- Genetic Association ofInternational journal of dentistry · 2017Article
- Grape seed extracts inhibit dentin matrix degradation by MMP-3.Frontiers in physiology · 2014Article
- Dentin matrix degradation by host matrix metalloproteinases: inhibition and clinical perspectives toward regeneration.Frontiers in physiology · 2013Review
- Dental enamel development: proteinases and their enamel matrix substrates.ISRN dentistry · 2013Review
- Role of the NH2 -terminal fragment of dentin sialophosphoprotein in dentinogenesis.European journal of oral sciences · 2013Article
- Immunohistochemical and biochemical assay of MMP-3 in human dentine.Journal of dentistry · 2011Article
- Differential effects of fibromodulin deficiency on mouse mandibular bones and teeth: a micro-CT time course study.Cells, tissues, organs · 2011Article
- Dentin: structure, composition and mineralization.Frontiers in bioscience (Elite edition) · 2011Review
- The NH2-terminal and COOH-terminal fragments of dentin matrix protein 1 (DMP1) localize differently in the compartments of dentin and growth plate of bone.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2009Article
- Fibromodulin-deficient mice reveal dual functions for fibromodulin in regulating dental tissue and alveolar bone formation.Cells, tissues, organs · 2009Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Stromelysin-1 (matrix metalloproteinase-3) or proteoglycanase was visualized by light and electron microscopy immunolabelling in the forming zone of rat incisors. In predentine, labelling was more dense at the transition zone between the inner proximal third and the two outer thirds. Odontoblast processes were also positively stained, mostly in predentine and to a lesser degree in dentine. The dentine-enamel junction was intensely labelled, whereas dentine and forming enamel were only faintly stained. Gold-antibodies complexes were seen inside secretory ameloblasts and odontoblasts in cytosolic locations. The distribution of stromelysin-1 was compared with the distribution of 2-B-6 epitope, an antibody recognizing chondroitin-4-sulphate/dermatan sulphate and which showed a decreasing gradient from the proximal zone to the distal part of predentine. In contrast, both 5-D-4, an anti-keratan sulphate antibody and an anti-lumican antibody displayed a reversed distribution, with an increase seen from the proximal and central thirds to the distal part of predentine. This coordinated distribution suggests that stromelysin-1 may have a functional role, being implicated in predentine in the degradation of chondroitin-4-sulphate/dermatan sulphate-containing proteoglycans, and consequently allowing keratan sulphate proteoglycan concentration to increase near the border where mineralization is initiated.
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Registered trials
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