ArticleProceedings of the National Academy of Sciences of the United States of America2000
Comparative genomic sequence analysis of the human and mouse cystic fibrosis transmembrane conductance regulator genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 71 citations in OpenAlex.
- Transamniotic Fetal Delivery of Cystic Fibrosis (CF) Transmembrane Conductance Regulator (CFTR) mRNA.FASEB bioAdvances · 2026Article
- Analyzing fourteen deleterious nsSNPs of CFTR as promising genetic markers for cancer prognosis.Scientific reports · 2026Article
- Article
- The relationship between common mutations in CFTR, AR genes, Y chromosome microdeletions and karyotyping abnormalities with very severe oligozoospermia in Iranian men.Genes & genomics · 2023Article
- Lung and Gut Microbiota Changes Associated withInternational journal of molecular sciences · 2021Article
- Fish-Ing for Enhancers in the Heart.International journal of molecular sciences · 2021Review
- Cystic Fibrosis Polymorphic Variants in a Russian Population.Pharmacogenomics and personalized medicine · 2020Article
- Low linoleic and high docosahexaenoic acids in a severe phenotype of transgenic cystic fibrosis mice.Experimental biology and medicine (Maywood, N.J.) · 2018Article
- Animal Models in the Pathophysiology of Cystic Fibrosis.Frontiers in pharmacology · 2018Review
- Essential Role of CFTR in PKA-Dependent Phosphorylation, Alkalinization, and Hyperpolarization During Human Sperm Capacitation.Journal of cellular physiology · 2017Article
- Complete ascertainment of intragenic copy number mutations (CNMs) in the CFTR gene and its implications for CNM formation at other autosomal loci.Human mutation · 2010Article
- CFTR and defective endocytosis: new insights in the renal phenotype of cystic fibrosis.Pflugers Archiv : European journal of physiology · 2009Review
- Transcription-dependent spatial arrangements of CFTR and conserved adjacent loci are not conserved in human and murine nuclei.Chromosoma · 2008Article
- EGASP: the human ENCODE Genome Annotation Assessment Project.Genome biology · 2006Review
- An intermediate grade of finished genomic sequence suitable for comparative analyses.Genome research · 2004Article
- Covariation in frequencies of substitution, deletion, transposition, and recombination during eutherian evolution.Genome research · 2003Article
- Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome.Genome research · 2002Article
- Association between divergence and interspersed repeats in mammalian noncoding genomic DNA.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5.Nucleic acids research · 2001Article
- Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element.Genome research · 2001Article
Corrections and comments
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Authors and funding
30 authors at 3 institutions in 1 country.
Funding
Abstract
The identification of the cystic fibrosis transmembrane conductance regulator gene (CFTR) in 1989 represents a landmark accomplishment in human genetics. Since that time, there have been numerous advances in elucidating the function of the encoded protein and the physiological basis of cystic fibrosis. However, numerous areas of cystic fibrosis biology require additional investigation, some of which would be facilitated by information about the long-range sequence context of the CFTR gene. For example, the latter might provide clues about the sequence elements responsible for the temporal and spatial regulation of CFTR expression. We thus sought to establish the sequence of the chromosomal segments encompassing the human CFTR and mouse Cftr genes, with the hope of identifying conserved regions of biologic interest by sequence comparison. Bacterial clone-based physical maps of the relevant human and mouse genomic regions were constructed, and minimally overlapping sets of clones were selected and sequenced, eventually yielding approximately 1.6 Mb and approximately 358 kb of contiguous human and mouse sequence, respectively. These efforts have produced the complete sequence of the approximately 189-kb and approximately 152-kb segments containing the human CFTR and mouse Cftr genes, respectively, as well as significant amounts of flanking DNA. Analyses of the resulting data provide insights about the organization of the CFTR/Cftr genes and potential sequence elements regulating their expression. Furthermore, the generated sequence reveals the precise architecture of genes residing near CFTR/Cftr, including one known gene (WNT2/Wnt2) and two previously unknown genes that immediately flank CFTR/Cftr.
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Registered trials
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