ArticleProceedings of the National Academy of Sciences of the United States of America2000
Localization of a peripheral membrane protein: Gbetagamma targets Galpha(Z).
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 52 citations in OpenAlex.
- Review
- Distinct RhoGEFs Activate Apical and Junctional Contractility under Control of G Proteins during Epithelial Morphogenesis.Current biology : CB · 2019Article
- The G alpha subunit Gα8 inhibits proliferation, promotes adhesion and regulates cell differentiation.Developmental biology · 2013Article
- G protein trafficking.Sub-cellular biochemistry · 2012Review
- Abscisic acid regulation of guard-cell K+ and anion channels in Gbeta- and RGS-deficient Arabidopsis lines.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Assembly and trafficking of heterotrimeric G proteins.Biochemistry · 2007Review
- Immunohistochemical localization of G protein betagamma subunits in the lateral wall of the rat cochlea.Journal of anatomy · 2006Article
- Excess of Gbetae over Gqalphae in vivo prevents dark, spontaneous activity of Drosophila photoreceptors.The Journal of cell biology · 2005Article
- Galpha subunit Gpa2 recruits kelch repeat subunits that inhibit receptor-G protein coupling during cAMP-induced dimorphic transitions in Saccharomyces cerevisiae.Molecular biology of the cell · 2005Article
- Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and Golgi.Molecular biology of the cell · 2002Article
- Characterization of subcellular localization and stability of a splice variant of G alpha i2.BMC cell biology · 2002Article
- N-terminal protein acylation confers localization to cholesterol, sphingolipid-enriched membranes but not to lipid rafts/caveolae.Molecular biology of the cell · 2001Article
- Mutant G protein alpha subunit activated by Gbeta gamma: a model for receptor activation?Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Regulation of G proteins by covalent modification.Oncogene · 2001Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
To explore the relative roles of protein-binding partners vs. lipid modifications in controlling membrane targeting of a typical peripheral membrane protein, Galpha(z), we directed its binding partner, betagamma, to mislocalize on mitochondria. Mislocalized betagamma directed wild-type Galpha(z) and a palmitate-lacking Galpha(z) mutant to mitochondria but did not alter localization of a Galpha(z) mutant lacking both myristate and palmitate. Thus, in this paradigm, a protein-protein interaction controls targeting of a peripheral membrane protein to the proper compartment, whereas lipid modifications stabilize interactions of proteins with membranes and with other proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.