Evidence map›Paper›PMID 10655480›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2000

A family of chromatin remodeling factors related to Williams syndrome transcription factor.

D A Bochar, J Savard, W Wang, D W Lafleur, P Moore, J Côté, R Shiekhattar

Abstract readComparative Study
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 147 citations in OpenAlex.

  1. SMARCA5 restricts chromatin accessibility to promote male meiosis and fertility in mammals.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  3. Pathogenic variants inScience advances · 2021
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  15. Bromodomains as therapeutic targets.Expert reviews in molecular medicine · 2011
    Review
  16. Review
  17. WSTF does it all: a multifunctional protein in transcription, repair, and replication.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2011
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

D A BocharThe Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.
J Savard
W Wang
D W Lafleur
P Moore
J Côté
R Shiekhattar
Hôtel-Dieu de Québec · CAInstitute of Aging · CAThe Wistar Institute · USHuman Genome Sciences (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chromatin remodeling complexes have been implicated in the disruption or reformation of nucleosomal arrays resulting in modulation of transcription, DNA replication, and DNA repair. Here we report the isolation of WCRF, a new chromatin-remodeling complex from HeLa cells. WCRF is composed of two subunits, WCRF135, the human homolog of Drosophila ISWI, and WCRF180, a protein related to the Williams syndrome transcription factor. WCRF180 is a member of a family of proteins sharing a putative heterochromatin localization domain, a PHD finger, and a bromodomain, prevalent in factors involved in regulation of chromatin structure.

Indexed as

Drosophila ProteinsNuclear ProteinsRNA-Binding ProteinsAdenosine TriphosphatasesAmino Acid SequenceAnimalsBromodomain Containing ProteinsChromatinChromosomal Proteins, Non-HistoneDeoxyribonuclease IDNA-Binding ProteinsDNA HelicasesDrosophila melanogasterFungal ProteinsHeLa CellsHumansAcf protein, DrosophilaAdenosine TriphosphatasesBAZ1A protein, humanBromodomain Containing ProteinsChromatinChromosomal Proteins, Non-HistoneDeoxyribonuclease IDNA-Binding ProteinsDNA HelicasesDrosophila ProteinsFungal ProteinsISWI proteinMacromolecular SubstancesNeoplasm ProteinsNuclear ProteinsNucleosomesRibonucleoprotein, U1 Small NuclearRNA-Binding ProteinsSMARCA1 protein, humanSMARCA2 protein, humanSMARCA4 protein, humansnf protein, DrosophilaTranscription Factors

Identifiers

PMID10655480
PMCPMC15513
OpenAlexW2085584897

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.