ArticleJournal of clinical microbiology2000
Serology of culture-confirmed cases of human granulocytic ehrlichiosis.
Article in Journal of clinical microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 73 citations in OpenAlex.
- Utility of combined detection of IgG/IgM/IgA vs. separate IgG and IgM antibodies to Anaplasma phagocytophilum in culture and PCR-confirmed patients with human granulocytic anaplasmosis.Wiener klinische Wochenschrift · 2026Article
- LAMP using distance based paper device for quantitative detection of ESBL producing Escherichia coli in UTI patients.Scientific reports · 2025Article
- Update on North American tick-borne diseases and how to diagnose them.Journal of clinical microbiology · 2025Review
- Antibodies to Anaplasma phagocytophilum in Patients with Human Granulocytic Anaplasmosis Confirmed by Both Polymerase Chain Reaction and Culture.The American journal of medicine · 2025Article
- Culture and other direct detection methods to diagnose human granulocytic anaplasmosis.American journal of clinical pathology · 2025Article
- Validation of quantitative loop-mediated isothermal amplification assay using a fluorescent distance-based paper device for detection of Escherichia coli in urine.Scientific reports · 2023Article
- Human granulocytic anaplasmosis in a Single University Hospital in the Republic of Korea.Scientific reports · 2021Article
- A new genetic approach to distinguish strains of Anaplasma phagocytophilum that appear not to cause human disease.Ticks and tick-borne diseases · 2021Article
- Case Report: Anaplasmosis in Canada: Locally AcquiredThe American journal of tropical medicine and hygiene · 2020Article
- Value of PCR, Serology, and Blood Smears for Human Granulocytic Anaplasmosis Diagnosis, France.Emerging infectious diseases · 2019Article
- Co-infections in Persons with Early Lyme Disease, New York, USA.Emerging infectious diseases · 2019Article
- Management approaches for suspected and established Lyme disease used at the Lyme disease diagnostic center.Wiener klinische Wochenschrift · 2018Article
- Article
- Retrospective Study Investigating the Seroprevalence ofOpen forum infectious diseases · 2016Article
- Comparison of a real-time PCR method with serology and blood smear analysis for diagnosis of human anaplasmosis: importance of infection time course for optimal test utilization.Journal of clinical microbiology · 2013Article
- Differences and similarities between culture-confirmed human granulocytic anaplasmosis and early lyme disease.Journal of clinical microbiology · 2013Article
- Cloning of the major outer membrane protein expression locus in Anaplasma platys and seroreactivity of a species-specific antigen.Journal of bacteriology · 2011Article
- Equine and canine Anaplasma phagocytophilum strains isolated on the island of Sardinia (Italy) are phylogenetically related to pathogenic strains from the United States.Applied and environmental microbiology · 2005Article
- Reinfection with Anaplasma phagocytophilum in BALB/c mice and cross-protection between two sympatric isolates.Infection and immunity · 2004Article
- In vivo and in vitro studies on Anaplasma phagocytophilum infection of the myeloid cells of a patient with chronic myelogenous leukaemia and human granulocytic ehrlichiosis.Journal of clinical pathology · 2004Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
We evaluated the antibody responses in the sera of 24 patients with culture-confirmed human granulocytic ehrlichiosis (HGE). Antibody titers were measured by an indirect immunofluorescent-antibody assay (IFA) by using a local human isolate as the source of antigen. All patients received appropriate antimicrobial treatment. One hundred five serum specimens collected at baseline and at periodic intervals for up to 14 months were included in the study. Seroconversion was observed in 21 of 23 patients (91.3%) from whom convalescent-phase sera were obtained. Antibodies were first detected at an average of 11.5 days after onset of symptoms. Peak titers (>/=2,560 for 71.4% of patients and >/=640 for 95.2% of patients) were obtained an average of 14.7 days after onset of symptoms. Eleven of 13 patients (84.6%) from whom sera were collected between 6 and 10 months after onset of symptoms were still seropositive, and sera from 5 of 10 (50%) patients tested positive between 11 and 14 months after onset of symptoms. For a subset of 71 serum specimens from 17 patients with culture-confirmed HGE also tested by IFA by using either a human isolate from Wisconsin or an Ehrlichia equi isolate from a horse, there was qualitative agreement for 62 serum specimens (87. 3%). Peak titers were higher, however, with the local human HGE isolate, but the difference was not statistically significant. In summary, most patients with culture-confirmed HGE develop antibodies within 2 weeks of onset of symptoms. Antibodies reach high titers during the first month and remain detectable in about one-half of patients at 1 year after onset of symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.