ArticleJournal of clinical microbiology2000
Species identification of Mycobacterium avium complex isolates by a variety of molecular techniques.
Article in Journal of clinical microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 59 citations in OpenAlex.
- Isolation and Characterization of Native Plasmids from Clinical Isolates ofIndian journal of microbiology · 2025Article
- Mycobacterium avium Complex Disease.Microbiology spectrum · 2017Review
- Identification of Mycobacterium spp. of veterinary importance using rpoB gene sequencing.BMC veterinary research · 2011Article
- Mycobacterium avium complex cervical lymphadenitis in an immunocompetent adult.Clinical and vaccine immunology : CVI · 2010Article
- Natural occurrence of horizontal transfer of Mycobacterium avium- specific insertion sequence IS1245 to Mycobacterium kansasii.Journal of clinical microbiology · 2010Article
- Identification and differentiation of clinically relevant mycobacterium species directly from acid-fast bacillus-positive culture broth.Journal of clinical microbiology · 2009Article
- Association between 16S-23S internal transcribed spacer sequence groups of Mycobacterium avium complex and pulmonary disease.Journal of clinical microbiology · 2008Article
- Genetic diversity of Mycobacterium avium isolates recovered from clinical samples and from the environment: molecular characterization for diagnostic purposes.Journal of clinical microbiology · 2008Article
- Mycobacterium avium in the postgenomic era.Clinical microbiology reviews · 2007Review
- Direct identification of mycobacteria in primary liquid detection media by partial sequencing of the 65-kilodalton heat shock protein gene.Journal of clinical microbiology · 2006Article
- Assessment of partial sequencing of the 65-kilodalton heat shock protein gene (hsp65) for routine identification of Mycobacterium species isolated from clinical sources.Journal of clinical microbiology · 2004Article
- Detection of Mycobacterium avium in blood samples of patients with AIDS by using PCR.Journal of clinical microbiology · 2002Article
- Evidence of the presence of IS1245 and IS1311 or closely related insertion elements in nontuberculous mycobacteria outside of the Mycobacterium avium complex.Journal of clinical microbiology · 2002Article
- Identification of Mycobacterium spp. by using a commercial 16S ribosomal DNA sequencing kit and additional sequencing libraries.Journal of clinical microbiology · 2002Article
- Phenotypic and genomic analyses of the Mycobacterium avium complex reveal differences in gastrointestinal invasion and genomic composition.Infection and immunity · 2001Article
- Characterization of a Mycobacterium intracellulare variant strain by molecular techniques.Journal of clinical microbiology · 2001Article
- Mapping of IS6110 insertion sites in two epidemic strains of Mycobacterium tuberculosis.Journal of clinical microbiology · 2000Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Organisms in the Mycobacterium avium complex (MAC; M. avium, M. intracellulare, and "nonspecific or X" MAC) are emerging pathogens among individual organisms of which significant genetic variability is displayed. The objective of the present study was to evaluate various molecular methods for the rapid and definitive identification of MAC species. Isolates were obtained from both human immunodeficiency virus (HIV)-positive patients and HIV-negative patients with and without known predisposing conditions. The isolates were initially hybridized with nucleic acid probes complementary to the rRNA of the respective mycobacterial species (AccuProbe Culture Confirmation kits for M. avium, M. intracellulare, and MAC species; Gen-Probe). Isolates were also examined by PCR and in some cases by Southern blot hybridization for the insertion element IS1245. Two other techniques included a PCR assay that amplifies the mig gene, a putative virulence factor for MAC, and hsp65 gene amplification and sequencing. This study led to the following observations. Eighty-five percent of the isolates from HIV-positive patients were M. avium and 86% of the isolates from HIV-negative patients were M. intracellulare. Fifteen of the M. avium isolates did not contain IS1245 and 7% of the M. intracellulare isolates were found to carry IS1245. All of the M. avium strains were mig positive, and all of the M. intracellulare strains were mig negative.
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