ArticleGenetics2000
Mutational analysis of a histone deacetylase in Drosophila melanogaster: missense mutations suppress gene silencing associated with position effect variegation.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 73 citations in OpenAlex.
- Single-cell dynamics of chromatin activity during cell lineage differentiation in Caenorhabditis elegans embryos.Molecular systems biology · 2021Article
- Histone deacetylase (Rpd3) regulatesOpen biology · 2020Article
- Systematic Analysis of SIN3 Histone Modifying Complex Components During Development.Scientific reports · 2018Article
- The histone deacetylase HDAC1 positively regulates Notch signaling duringBiology open · 2018Article
- The effects of reducedNutrition and healthy aging · 2017Article
- The effects of Rpd3 on fly metabolism, health, and longevity.Experimental gerontology · 2016Review
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- RPD3 histone deacetylase and nutrition have distinct but interacting effects on Drosophila longevity.Aging · 2015Article
- Position-effect variegation, heterochromatin formation, and gene silencing in Drosophila.Cold Spring Harbor perspectives in biology · 2013Review
- Article
- Histone deacetylase Rpd3 regulates olfactory projection neuron dendrite targeting via the transcription factor Prospero.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Loss of the SIN3 transcriptional corepressor results in aberrant mitochondrial function.BMC biochemistry · 2010Article
- Widespread regulation of gene expression in the Drosophila genome by the histone acetyltransferase dTip60.Chromosoma · 2010Article
- The H3K4 demethylase lid associates with and inhibits histone deacetylase Rpd3.Molecular and cellular biology · 2009Article
- Differential effects of class I isoform histone deacetylase depletion and enzymatic inhibition by belinostat or valproic acid in HeLa cells.Molecular cancer · 2008Article
- Atrophin recruits HDAC1/2 and G9a to modify histone H3K9 and to determine cell fates.EMBO reports · 2008Article
- Epigenetic blocking of an enhancer region controls irradiation-induced proapoptotic gene expression in Drosophila embryos.Developmental cell · 2008Article
- Drosophila histone deacetylase-3 controls imaginal disc size through suppression of apoptosis.PLoS genetics · 2008Article
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Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For many years it has been noted that there is a correlation between acetylation of histones and an increase in transcriptional activity. One prediction, based on this correlation, is that hypomorphic or null mutations in histone deacetylase genes should lead to increased levels of histone acetylation and result in increased levels of transcription. It was therefore surprising when it was reported, in both yeast and fruit flies, that mutations that reduced or eliminated a histone deacetylase resulted in transcriptional silencing of genes subject to telomeric and heterochromatic position effect variegation (PEV). Here we report the first mutational analysis of a histone deacetylase in a multicellular eukaryote by examining six new mutations in HDAC1 of Drosophila melanogaster. We observed a suite of phenotypes accompanying the mutations consistent with the notion that HDAC1 acts as a global transcriptional regulator. However, in contrast to recent findings, here we report that specific missense mutations in the structural gene of HDAC1 suppress the silencing of genes subject to PEV. We propose that the missense mutations reported here are acting as antimorphic mutations that "poison" the deacetylase complex and propose a model that accounts for the various phenotypes associated with lesions in the deacetylase locus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.