ArticleGenetics2000
Telomere structure regulates the heritability of repressed subtelomeric chromatin in Saccharomyces cerevisiae.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Genomic Landscape Underlying Biofilm Formation Diversity in Nakaseomyces glabratus Clinical Isolates.MicrobiologyOpen · 2026Article
- Reciprocal interactions between mtDNA and lifespan control in budding yeast.Molecular biology of the cell · 2019Article
- The Ku subunit of telomerase binds Sir4 to recruit telomerase to lengthen telomeres in S. cerevisiae.eLife · 2015Article
- Heat stress-induced Cup9-dependent transcriptional regulation of SIR2.Molecular and cellular biology · 2015Article
- Epigenetics in Saccharomyces cerevisiae.Cold Spring Harbor perspectives in biology · 2013Review
- Epigenetic silencing mediates mitochondria stress-induced longevity.Cell metabolism · 2013Article
- Mechanism for epigenetic variegation of gene expression at yeast telomeric heterochromatin.Genes & development · 2012Article
- SIRT6 is required for maintenance of telomere position effect in human cells.Nature communications · 2011Article
- Sir3 C-terminal domain involvement in the initiation and spreading of heterochromatin.Molecular and cellular biology · 2006Article
- Multiple roles for Saccharomyces cerevisiae histone H2A in telomere position effect, Spt phenotypes and double-strand-break repair.Genetics · 2003Article
- Mutant telomeres inhibit transcriptional silencing at native telomeres of the yeast Kluyveromyces lactis.Molecular genetics and genomics : MGG · 2003Article
- Yeast hnRNP K-like genes are involved in regulation of the telomeric position effect and telomere length.Molecular and cellular biology · 2002Article
- Intrachromatid excision of telomeric DNA as a mechanism for telomere size control in Saccharomyces cerevisiae.Molecular and cellular biology · 2001Article
- Telomere folding is required for the stable maintenance of telomere position effects in yeast.Molecular and cellular biology · 2000Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Telomeres, the protein-DNA structures present at the termini of linear chromosomes, are capable of conferring a reversible repression of Pol II- and Pol III-transcribed genes positioned in adjacent subtelomeric regions. This phenomenon, termed telomeric silencing, is likely to be the consequence of a more global telomere position effect at the level of chromatin structure. To understand the role of telomere structure in this position effect, we have developed an assay to distinguish between the heritability of transcriptionally repressed and derepressed states in yeast. We have previously demonstrated that an elongated telomeric tract leads to hyperrepression of telomere-adjacent genes. We show here that the predominant effect of elongated telomeres is to increase the inheritance of the repressed state in cis. Interestingly, the presence of elongated telomeres overcomes the partial requirement of yCAF-1 in silencing. We propose that the formation of a specific telomeric structure is necessary for the heritability of repressed subtelomeric chromatin.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.