ArticleBiophysical journal2000
Membrane fusion mediated by coiled coils: a hypothesis.
Article in Biophysical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 114 citations in OpenAlex.
- Aspects of Biological Replication and Evolution Independent of the Central Dogma: Insights from Protein-Free Vesicular Transformations and Protein-Mediated Membrane Remodeling.The Journal of membrane biology · 2022Article
- Role of the Ebola membrane in the protection conferred by the three-mAb cocktail MIL77.Scientific reports · 2018Article
- Dynamic changes during acid-induced activation of influenza hemagglutinin.Structure (London, England : 1993) · 2015Article
- Dramatic potentiation of the antiviral activity of HIV antibodies by cholesterol conjugation.The Journal of biological chemistry · 2014Article
- Order and disorder control the functional rearrangement of influenza hemagglutinin.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Structural characterization of a fusion glycoprotein from a retrovirus that undergoes a hybrid 2-step entry mechanism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Cell entry of enveloped viruses.Current opinion in virology · 2011Review
- The final conformation of the complete ectodomain of the HA2 subunit of influenza hemagglutinin can by itself drive low pH-dependent fusion.The Journal of biological chemistry · 2011Article
- Viral entry inhibitors targeted to the membrane site of action.Journal of virology · 2010Article
- Addition of a cholesterol group to an HIV-1 peptide fusion inhibitor dramatically increases its antiviral potency.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Viral and developmental cell fusion mechanisms: conservation and divergence.Developmental cell · 2008Review
- Article
- Membrane hemifusion is a stable intermediate of exocytosis.Developmental cell · 2007Article
- Crystal structures of Nipah and Hendra virus fusion core proteins.The FEBS journal · 2006Article
- Triggering and visualizing the aggregation and fusion of lipid membranes in microfluidic chambers.Biophysical journal · 2006Article
- Stoichiometry of envelope glycoprotein trimers in the entry of human immunodeficiency virus type 1.Journal of virology · 2005Article
- Liposome reconstitution of a minimal protein-mediated membrane fusion machine.The EMBO journal · 2005Article
- Crystallization and preliminary X-ray diffraction analysis of central structure domains from mumps virus F protein.Acta crystallographica. Section F, Structural biology and crystallization communications · 2005Article
- The C terminus of the B5 receptor for herpes simplex virus contains a functional region important for infection.Journal of virology · 2005Article
- Unusual topological arrangement of structural motifs in the baboon reovirus fusion-associated small transmembrane protein.Journal of virology · 2005Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A molecular model of the low-pH-induced membrane fusion by influenza hemagglutinin (HA) is proposed based upon the hypothesis that the conformational change to the extended coiled coil creates a high-energy hydrophobic membrane defect in the viral envelope or HA expressing cell. It is known that 1) an aggregate of at least eight HAs is required at the fusion site, yet only two or three of these HAs need to undergo the "essential" conformational change for the first fusion pore to form (Bentz, J. 2000. Biophys. J. 78:000-000); 2) the formation of the first fusion pore signifies a stage of restricted lipid flow into the nascent fusion site; and 3) some HAs can partially insert their fusion peptides into their own viral envelopes at low pH. This suggests that the committed step for HA-mediated fusion begins with a tightly packed aggregate of HAs whose fusion peptides are inserted into their own viral envelope, which causes restricted lateral lipid flow within the HA aggregate. The transition of two or three HAs in the center of the aggregate to the extended coiled coil extracts the fusion peptide and creates a hydrophobic defect in the outer monolayer of the virion, which is stabilized by the closely packed HAs. These HAs are inhibited from diffusing away from the site to admit lateral lipid flow, in part because that would initially increase the surface area of hydrophobic exposure. The other obvious pathway to heal this hydrophobic defect, or some descendent, is recruitment of lipids from the outer monolayer of the apposed target membrane, i.e., fusion. Other viral fusion proteins and the SNARE fusion protein complex appear to fit within this hypothesis.
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